دورية أكاديمية
Shear wave elastography detects novel imaging biomarkers of aromatase inhibitor–induced joint pain: a pilot study
| العنوان: | Shear wave elastography detects novel imaging biomarkers of aromatase inhibitor–induced joint pain: a pilot study |
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| المؤلفون: | Martinez Jessica A., Taljanovic Mihra S., Witte Russell S., Nuncio Zuniga Andres A., Wertheim Betsy C., Kwoh C. Kent, Goldstein Brian A., Roe Denise J., Chalasani Pavani |
| المصدر: | Journal of Ultrasonography, Vol 21, Iss 84, Pp 1-6 (2021) |
| بيانات النشر: | Sciendo, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine (General) LCC:Medical technology |
| مصطلحات موضوعية: | aromatase inhibitors, breast cancer, arthralgia, doppler ultrasound, shear wave elastography, Medicine (General), R5-920, Medical technology, R855-855.5 |
| الوصف: | Aim: To determine whether differences in joint and tendon stiffness as measured by ultrasound shear wave elastography are present in breast cancer patients with aromatase inhibitor-associated arthralgias compared to age-comparable healthy control women. Methods: Postmenopausal women with stage I–III breast cancer who were taking adjuvant aromatase inhibitors and complained of joint pain were enrolled (n = 6). Postmenopausal women with no history of breast cancer, hormone treatment, or joint pain served as controls (n = 7). All subjects had bilateral hands and wrists evaluated by gray-scale and power Doppler ultrasound, and shear wave elastography ultrasound. Results: Patients with AI-associated arthralgias had significantly stiffer tendons than controls in the 1st extensor compartment (long axis; p = 0.001), 4th extensor compartment (long axis; p = 0.014), 3rd metacarpophalangeal joint (p = 0.002), the pooled values of the extensor compartments, both long (p = 0.044) and short axes (p = 0.035), and the pooled values for the metacarpophalangeal joints (p = 0.002). On ultrasound, the patients (but not controls) presented with hyperemia and increased tenosynovial fluid in the flexor and extensor tendon sheaths, and the median nerves were symptomatic and bifid; however, these differences were not statistically significant. Conclusions: This is the first study to identify increased tendon stiffness as a putative physiological characteristic of aromatase inhibitor–associated arthralgias. Future studies should determine whether increased tendon stiffness is a risk factor for the development of aromatase inhibitor–associated arthralgias, or a result of aromatase inhibitor treatment. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2451-070X 65905210 |
| العلاقة: | https://doaj.org/toc/2451-070XTest |
| DOI: | 10.15557/jou.2021.0001 |
| الوصول الحر: | https://doaj.org/article/a659052105214a3ba9f82f9e2440dc4eTest |
| رقم الانضمام: | edsdoj.659052105214a3ba9f82f9e2440dc4e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2451070X 65905210 |
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| DOI: | 10.15557/jou.2021.0001 |