التفاصيل البيبلوغرافية
| العنوان: |
The Effects of Gamma and Proton Radiation Exposure on Hematopoietic Cell Counts in the Ferret Model. |
| المؤلفون: |
Sanzari, Jenine K., Wan, X. Steven, Krigsfeld, Gabriel S., Wroe, Andrew J., Gridley, Daila S., Kennedy, Ann R. |
| المصدر: |
Gravitational & Space Research; Oct2013, Vol. 1 Issue 1, p79-94, 16p |
| مصطلحات موضوعية: |
GAMMA rays, HEMATOPOIETIC system, HEMATOLOGY, PROTONS, BLOOD cell count |
| مستخلص: |
Exposure to total-body radiation induces hematological changes, which can detriment one's immune response to wounds and infection. Here, the decreases in blood cell counts after acute radiation doses of γ-ray or proton radiation exposure, at the doses and dose-rates expected during a solar particle event (SPE), are reported in the ferret model system. Following the exposure to γ-ray or proton radiation, the ferret peripheral total white blood cell (WBC) and lymphocyte counts decreased whereas neutrophil count increased within 3 hours. At 48 hours after irradiation, the WBC, neutrophil, and lymphocyte counts decreased in a dose-dependent manner but were not significantly affected by the radiation type (γ-rays verses protons) or dose rate (0.5 Gy/minute verses 0.5 Gy/hour). The loss of these blood cells could accompany and contribute to the physiological symptoms of the acute radiation syndrome (ARS). [ABSTRACT FROM AUTHOR] |
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