دورية أكاديمية
A Variance-Stabilizing Transformation for Gene-Expression Microarray Data
| العنوان: | A Variance-Stabilizing Transformation for Gene-Expression Microarray Data |
|---|---|
| المؤلفون: | Durbin, B.P., Hardin, Johanna S., Hawkins, D.M., Rocke, David M. |
| المصدر: | Pomona Faculty Publications and Research |
| بيانات النشر: | Scholarship @ Claremont |
| سنة النشر: | 2002 |
| المجموعة: | Claremont Colleges: Scholarship@Claremont |
| مصطلحات موضوعية: | cDNA array, microarray, statistical analysis, transformation, normalization, Mathematics, Microarrays, Physical Sciences and Mathematics, Statistics and Probability |
| الوصف: | Motivation: Standard statistical techniques often assume that data are normally distributed, with constant variance not depending on the mean of the data. Data that violate these assumptions can often be brought in line with the assumptions by application of a transformation. Gene-expression microarray data have a complicated error structure, with a variance that changes with the mean in a non-linear fashion. Log transformations, which are often applied to microarray data, can inflate the variance of observations near background. Results: We introduce a transformation that stabilizes the variance of microarray data across the full range of expression. Simulation studies also suggest that this transformation approximately symmetrizes microarray data. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://scholarship.claremont.edu/pomona_fac_pub/292Test; http://bioinformatics.oxfordjournals.org/content/18/suppl_1/S105Test |
| الإتاحة: | https://scholarship.claremont.edu/pomona_fac_pub/292Test http://bioinformatics.oxfordjournals.org/content/18/suppl_1/S105Test |
| حقوق: | © 2002 Oxford University Press ; default |
| رقم الانضمام: | edsbas.F9117AF |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |