دورية أكاديمية
Increased circulating monocyte MDSCs positively correlate with serum Interleukin-10 in metastatic melanoma patients
| العنوان: | Increased circulating monocyte MDSCs positively correlate with serum Interleukin-10 in metastatic melanoma patients |
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| المؤلفون: | Katarina Mirjačić Martinović, Ana Vuletić, Nevena Tišma Miletić, Milica Nedeljković, Nada Babović, Suzana Matković, Vladimir Jurišić |
| المصدر: | Innate Immunity, Vol 29 (2023) |
| بيانات النشر: | SAGE Publishing |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Immunologic diseases. Allergy, RC581-607 |
| الوصف: | Numerous immunosuppressive cells such as myeloid-derived suppressor cells (MDSCs) and inhibitory cytokines identified in melanoma microenvironment have the important role in immune escape. Therefore, in this study we analyzed monocytic (m)MDSCs in peripheral blood of metastatic melanoma (MM) patients. In peripheral blood of 35 MM patients and 30 healthy controls we analyzed percentage of CD14 + HLA-DR- mMDSCs in monocyte gate and the mean fluorescence intensity of Foxp3 in CD25 + CD4 + regulatory T cells by Flow cytometry. Serum levels of transforming growth factor beta, interferon-gamma, interleukin (IL)-6, IL-8, IL-10 are measured by ELISA assays. In this study MM patients have significantly higher percentage of CD14 + HLA-DR- mMDSCs, as well as increased the baseline mMDSC/PBMC subset (NK, T, B cells, monocytes) ratio. Although there is no significant difference in the percentage of mMDSCs between groups of MM patients with different localization of distant metastasis, patients with elevated serum lactate dehydrogenase (LDH) have statistically significant higher percentage of these cells compared to LDH negative patients. Furthermore, in MM patients there is statistically significant positive correlation between values of IL-10 and the percentage of mMDSCs, only. Therefore, therapeutics that target circulating mMDSCs and IL-10 may have a big importance in the improvement of antitumor immunity in MM patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1753-4259 1753-4267 |
| العلاقة: | https://doi.org/10.1177/17534259231172079Test; https://doaj.org/toc/1753-4259Test; https://doaj.org/toc/1753-4267Test; https://doaj.org/article/bfad43c388fe4c2e9c99b01043f88417Test |
| DOI: | 10.1177/17534259231172079 |
| الإتاحة: | https://doi.org/10.1177/17534259231172079Test https://doaj.org/article/bfad43c388fe4c2e9c99b01043f88417Test |
| رقم الانضمام: | edsbas.E98AF4EA |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 17534259 17534267 |
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| DOI: | 10.1177/17534259231172079 |