دورية أكاديمية
Calcium channel blockers and Parkinson’s disease: a systematic review and meta-analysis
| العنوان: | Calcium channel blockers and Parkinson’s disease: a systematic review and meta-analysis |
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| المؤلفون: | Junyu Lin, Dejiang Pang, Chunyu Li, Ruwei Ou, Yujiao Yu, Yiyuan Cui, Jingxuan Huang, Huifang Shang |
| المصدر: | Therapeutic Advances in Neurological Disorders, Vol 17 (2024) |
| بيانات النشر: | SAGE Publishing, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Background: The calcium channel has been considered to have great potential as a drug target for neuroprotective therapy in Parkinson’s disease (PD), but previous studies yielded inconsistent results. Objectives: This study aimed to conduct a systematic review and meta-analysis to assess the relationship between using calcium channel blockers (CCBs) and the risk and progression of PD. Data sources and methods: The terms such as ‘Parkinson’s disease’, ‘PD’, ‘calcium channel blockers’, and ‘CCB’ were used to search the literature published before 1 May 2023 in English databases, including PubMed, Embase, and Cochrane Library, for studies on CCB and PD. Data analysis was performed using Review Manager 5.3 software. Results: A total of 190 works of literature were preliminarily retrieved, and 177 works of literature were excluded by eliminating duplicates, reading abstracts, and reading full texts. A total of nine studies were finally included in the meta-analysis of the CCB and the risk of PD, and five studies were included in the systematic review of the CCB and the progression of PD. A total of 2,961,695 participants were included in the meta-analysis. The random-effects model was used for analysis due to significant heterogeneity. The main results of the meta-analysis showed that the use of CCB could reduce the risk of PD (relative risk 0.78, 95% confidence interval 0.62–0.99). Conclusion: CCB use was associated with a significantly reduced risk of PD. Whether CCB use has a disease-modifying effect on PD needs further study. Registration: PROSPERO: CRD42024508242. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1756-2864 17562864 |
| العلاقة: | https://doaj.org/toc/1756-2864Test |
| DOI: | 10.1177/17562864241252713 |
| الوصول الحر: | https://doaj.org/article/f4b4ff81d14e474b8de719627fb93663Test |
| رقم الانضمام: | edsdoj.f4b4ff81d14e474b8de719627fb93663 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17562864 |
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| DOI: | 10.1177/17562864241252713 |