دورية أكاديمية
PD-1 Deficiency in Regulatory T Cells May be Involved in the Pathogenesis of Takayasu's Arteritis
| العنوان: | PD-1 Deficiency in Regulatory T Cells May be Involved in the Pathogenesis of Takayasu's Arteritis |
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| المؤلفون: | Na Gao PhD, Taoao Li PhD, Wei Cui BS, Limin Zhao BS, Jianghui Zhang PhD, Lili Pan PhD |
| المصدر: | Clinical and Applied Thrombosis/Hemostasis, Vol 29 (2023) |
| بيانات النشر: | SAGE Publishing, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Objectives This study aims to investigate whether PD-1 expressions are abnormal in patients with TAK. Methods PD-1 expression was analyzed by flow cytometry. Serum cytokines IL-10, IL-7, IL-2, IL-15, CCL2, CCL3, and CXCL10 were detected using a cytokine cytometric bead array. Immunohistochemistry staining analysis was used to test PD-1 and programmed death-ligand 1 (PD-L1) expression in the aorta of three patients with TAK and three patients with atherosclerosis as controls. Results The mean fluorescence intensity of PD-1 in CD4 + PD-1 + cells was decreased in patients with TAK and the frequency of CD4 + Foxp3 − PD-1 + cells among CD4 + T cells was also decreased in peripheral blood relative to healthy controls ( P .05). Patients with TAK had higher serum levels of IL-10, IL-7, CCL2, and CCL3 ( P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1938-2723 10760296 |
| العلاقة: | https://doaj.org/toc/1938-2723Test |
| DOI: | 10.1177/10760296231187896 |
| الوصول الحر: | https://doaj.org/article/878bcede14234368a3daa4b3fa9b3263Test |
| رقم الانضمام: | edsdoj.878bcede14234368a3daa4b3fa9b3263 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19382723 10760296 |
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| DOI: | 10.1177/10760296231187896 |