دورية أكاديمية
Androgen receptor molecular biology and potential targets in prostate cancer
| العنوان: | Androgen receptor molecular biology and potential targets in prostate cancer |
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| المؤلفون: | Elizabeth M. Wilson |
| المصدر: | Therapeutic Advances in Urology, Vol 2 (2010) |
| بيانات النشر: | SAGE Publishing, 2010. |
| سنة النشر: | 2010 |
| المجموعة: | LCC:Diseases of the genitourinary system. Urology |
| مصطلحات موضوعية: | Diseases of the genitourinary system. Urology, RC870-923 |
| الوصف: | The androgen receptor (AR) is a key transcriptional regulator and therapeutic target in prostate cancer. During androgen deprivation therapy to treat metastatic prostate cancer, surviving cells acquire increased AR signaling through a variety of mechanisms, one of which is enhanced interactions with AR coactivators. One recently identified AR-specific coregulator expressed only in human and nonhuman primates is the melanoma antigen gene protein-A11 (MAGE-11). MAGE-11 increases AR transcriptional activity through direct interactions with AR and other coactivators, and its levels increase during prostate cancer progression to castration-recurrent growth. The MAGE-11 gene is located at Xq28 on the human X chromosome as part of an X-linked MAGE gene family of cancer—testis antigens. MAGE-11 stabilizes AR when androgen levels are low, and functions in a transcriptional hub to promote AR-mediated gene activation. The evolutionary development and organization of the MAGE-11 gene within the cancer—testis antigen family suggests that MAGE-11 provides a gain-of-function to AR among primates in both normal physiology and cancer, and may serve as a therapeutic target in the treatment of advanced prostate cancer. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1756-2872 17562872 |
| العلاقة: | https://doaj.org/toc/1756-2872Test |
| DOI: | 10.1177/1756287210372380 |
| الوصول الحر: | https://doaj.org/article/bb863f63d571462494aa1b49af60cc47Test |
| رقم الانضمام: | edsdoj.bb863f63d571462494aa1b49af60cc47 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17562872 |
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| DOI: | 10.1177/1756287210372380 |