دورية أكاديمية
Effects of an Exercise and Nutritional Intervention on Circulating Biomarkers and Metabolomic Profiling During Adjuvant Treatment for Localized Breast Cancer: Results From the PASAPAS Feasibility Randomized Controlled Trial
| العنوان: | Effects of an Exercise and Nutritional Intervention on Circulating Biomarkers and Metabolomic Profiling During Adjuvant Treatment for Localized Breast Cancer: Results From the PASAPAS Feasibility Randomized Controlled Trial |
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| المؤلفون: | Olivia Febvey-Combes MD, Elodie Jobard PhD, Adrien Rossary PharmD, PhD, Vincent Pialoux PhD, Aude-Marie Foucaut PhD, Magali Morelle MSc, Lidia Delrieu PhD, Agnès Martin MSc, Florence Caldefie-Chézet PharmD, PhD, Marina Touillaud PhD, Sophie E. Berthouze PhD, Houda Boumaza PhD, Bénédicte Elena-Herrmann PhD, Patrick Bachmann MD, Olivier Trédan MD, PhD, Marie-Paule Vasson PharmD, PhD, Béatrice Fervers MD, PhD |
| المصدر: | Integrative Cancer Therapies, Vol 20 (2021) |
| بيانات النشر: | SAGE Publishing |
| سنة النشر: | 2021 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Purpose: Exercise has been shown to improve physical and psychological conditions during cancer therapy, but mechanisms remain poorly understood. The purpose of the present study was to report the results of cancer-related biomarkers and metabolomics outcomes from the PASAPAS feasibility study. Methods: In the PASAPAS randomized controlled trial, 61 women beginning adjuvant chemotherapy for localized breast cancer were randomized in a 6-month program of weekly aerobic exercises associated with nutritional counseling versus usual care with nutritional counseling. In the present analysis of 58 women for whom blood samples were available, first, circulating levels of biomarkers (ie, insulin, insulin-like growth factor 1, estradiol, adiponectin, leptin, interleukin-6, and tumor necrosis factor α) were measured at baseline and 6-month follow-up. Changes in biomarkers were compared between exercisers (n = 40) and controls (n = 18) using mixed-effect models. Second, serum metabolites were studied using an untargeted 1 H nuclear magnetic resonance spectroscopy, and orthogonal partial least squares analyses were performed to discriminate exercisers and controls at baseline and at 6 months. Results: Over the 6-month intervention, no statistically significant differences were observed between exercisers and controls regarding changes in biomarkers and metabolomic profiles. Conclusion: The present analysis of the PASAPAS feasibility trial did not reveal any improvement in circulating biomarkers nor identified metabolic signatures in exercisers versus controls during adjuvant breast cancer treatment. Larger studies preferably in women with poor physical activity level to avoid ceiling effect, testing different doses and types of exercise on additional biological pathways, could allow to clarify the mechanisms mediating beneficial effects of physical exercise during cancer treatment. Trial registration: ClinicalTrials.gov Identifier: NCT01331772. Registered 8 April 2011, ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1534-7354 1552-695X |
| العلاقة: | https://doi.org/10.1177/1534735420977666Test; https://doaj.org/toc/1534-7354Test; https://doaj.org/toc/1552-695XTest; https://doaj.org/article/7abebffac23f4defa6746abcbd6ee9f5Test |
| DOI: | 10.1177/1534735420977666 |
| الإتاحة: | https://doi.org/10.1177/1534735420977666Test https://doaj.org/article/7abebffac23f4defa6746abcbd6ee9f5Test |
| رقم الانضمام: | edsbas.B78AABF7 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 15347354 1552695X |
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| DOI: | 10.1177/1534735420977666 |