The Increasing Prevalence in Intersex Variation from Toxicological Dysregulation in Fetal Reproductive Tissue Differentiation and Development by Endocrine-Disrupting Chemicals
| العنوان: | The Increasing Prevalence in Intersex Variation from Toxicological Dysregulation in Fetal Reproductive Tissue Differentiation and Development by Endocrine-Disrupting Chemicals |
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| المؤلفون: | Laura M. Phipps, Alisa L. Rich, Sweta Tiwari, Philip O. Dokpesi, Hemanth Rudraraju |
| المصدر: | Environmental Health Insights, Vol 2016, Iss 10, Pp 163-171 (2016) Environmental Health Insights Environmental Health Insights, Vol 10 (2016) |
| بيانات النشر: | SAGE Publishing, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Gender dysphoria, ambiguous genitalia, Offspring, Health, Toxicology and Mutagenesis, fetal development, Physiology, 030209 endocrinology & metabolism, Review, Management, Monitoring, Policy and Law, Biology, Bioinformatics, 03 medical and health sciences, 0302 clinical medicine, Hermaphrodite, medicine, Endocrine system, Pseudohermaphroditism, reproductive birth defect, lcsh:Environmental sciences, lcsh:GE1-350, lcsh:Public aspects of medicine, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, intersex variation, pesticides, Sex reversal, medicine.disease, endocrine disrupting chemicals, Pollution, 030104 developmental biology, In utero, Animal studies |
| الوصف: | An increasing number of children are born with intersex variation (IV; ambiguous genitalia/hermaphrodite, pseudohermaphroditism, etc.). Evidence shows that endocrine-disrupting chemicals (EDCs) in the environment can cause reproductive variation through dysregulation of normal reproductive tissue differentiation, growth, and maturation if the fetus is exposed to EDCs during critical developmental times in utero. Animal studies support fish and reptile embryos exhibited IV and sex reversal when exposed to EDCs. Occupational studies verified higher prevalence of offspring with IV in chemically exposed workers (male and female). Chemicals associated with endocrine-disrupting ability in humans include organochlorine pesticides, polychlorinated biphenyls, bisphenol A, phthalates, dioxins, and furans. Intersex individuals may have concurrent physical disorders requiring lifelong medical intervention and experience gender dysphoria. An urgent need exists to determine which chemicals possess the greatest risk for IV and the mechanisms by which these chemicals are capable of interfering with normal physiological development in children. |
| اللغة: | English |
| تدمد: | 1178-6302 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf2756798c915f93794f49a5d2ad967Test http://www.la-press.com/the-increasing-prevalence-in-intersex-variation-from-toxicological-dys-article-a5890Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....aaf2756798c915f93794f49a5d2ad967 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 11786302 |
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