Calibration of Baroreflex Equilibrium Diagram Based on Exogenous Pressor Agents in Chronic Heart Failure Rats
| العنوان: | Calibration of Baroreflex Equilibrium Diagram Based on Exogenous Pressor Agents in Chronic Heart Failure Rats |
|---|---|
| المؤلفون: | Michael J. Turner, Can Zheng, Masaru Sugimachi, Meihua Li, Shuji Shimizu, Toru Kawada, Yusuke Sata |
| المصدر: | Clinical Medicine Insights: Cardiology, Vol 9s1 (2015) Clinical Medicine Insights. Cardiology Clinical Medicine Insights: Cardiology, Vol 2015, Iss Suppl. 1, Pp 1-9 (2015) |
| بيانات النشر: | SAGE Publishing, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, Equilibrium diagram, NC ratio, Baroreflex, norepinephrine, Norepinephrine (medication), Internal medicine, medicine, cardiovascular diseases, carotid sinus baroreflex, Phenylephrine, Original Research, business.industry, Sympathetic nerve activity, open-loop analysis, medicine.disease, phenylephrine, body regions, Blood pressure, lcsh:RC666-701, Heart failure, Cardiology, arterial pressure, Cardiology and Cardiovascular Medicine, business, medicine.drug, Biomedical engineering, circulatory and respiratory physiology |
| الوصف: | A baroreflex equilibrium diagram describes the relation between input pressure and sympathetic nerve activity (SNA) and that between SNA and arterial pressure (AP). To calibrate the SNA axis (abscissa) of the baroreflex equilibrium diagram, the AP response to intravenous bolus injections of phenylephrine (0.2-50 μg/kg) or norepinephrine (NE, 0.02-5 μg/kg) was examined in normal control rats (NC, n = 9) and rats with chronic heart failure (CHF, n = 6). The maximum slope of the dose–effect curve was significantly smaller in the CHF group than in the NC group (57.3 ± 5.2 vs 80.9 ± 6.3 mmHg/decade for phenylephrine, 60.2 ± 7.8 vs 80.4 ± 5.9 mmHg/decade for NE; P < 0.01). The CHF/NC ratio of the maximum slope was used to calibrate SNA. While the calibrated baroreflex equilibrium diagram showed increased maximum SNA and operating-point SNA in CHF rats compared with NC rats, the magnitude of increase was smaller than that expected from the excess plasma NE concentration in CHF rats. Plasma NE concentration in the CHF group could be disproportionally high relative to SNA. |
| اللغة: | English |
| تدمد: | 1179-5468 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d2c131a6d73e334f09c98b3dd8b741Test https://doaj.org/article/1478178f01954312a3d7425b484cc31bTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e5d2c131a6d73e334f09c98b3dd8b741 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 11795468 |
|---|