دورية أكاديمية
In vivo study of polyurethane and tannin-modified hydroxyapatite composites for calvarial regeneration
| العنوان: | In vivo study of polyurethane and tannin-modified hydroxyapatite composites for calvarial regeneration |
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| المؤلفون: | Xinggui Tian, Xiaowei Yuan, Daxiong Feng, Min Wu, Yuping Yuan, Chuying Ma, Denghui Xie, Jinshan Guo, Chao Liu, Zhihui Lu |
| المصدر: | Journal of Tissue Engineering, Vol 11 (2020) |
| بيانات النشر: | SAGE Publishing, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Biochemistry |
| مصطلحات موضوعية: | Biochemistry, QD415-436 |
| الوصف: | Biomaterial mediated bone regeneration is an attractive strategy for bone defect treatment. Organic/inorganic composites have been well established as effective bone graft. Here, the bone regenerative effect of the composites made from tannic acid (TA) modified hydroxyapatite (HA) (THA) or TA & silver nanoparticles (Ag NPs) modified HA (Ag-THA) and polyurethane (PU) was evaluated on critical-sized calvarial defects in rats. The in vivo study indicates that PU/THA and PU/Ag-THA scaffolds exhibited acceptable biocompatibility and induced significantly enhanced bone mineral densities comparing with the blank control (CON) group as well as PU/HA group. The inclusion of TA on HA brought the composites with enhanced osteogenesis and angiogenesis, evidenced by osteocalcin (OCN) and vascular endothelial growth factor (VEGF) immunohistochemical staining. Tartrate resistant acid phosphatase (TRAP) staining showed high osteoclast activity along with osteogenesis, especially in PU/THA and PU/Ag-THA groups. However, further introduction of Ag NPs on HA depressed the angiogenesis of the composites, leading to even lower VEGF expression than that of CON group. This study once more proved that THA can serve as a better bone composite component that pure HA and can promote osteogenesis and angiogenesis. While, the introduction of antimicrobial Ag NPs on HA need to be controlled in some extent not to affect the angiogenesis of the composites. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2041-7314 20417314 |
| العلاقة: | https://doaj.org/toc/2041-7314Test |
| DOI: | 10.1177/2041731420968030 |
| الوصول الحر: | https://doaj.org/article/61fb72393f95426b8e92e43405f0429cTest |
| رقم الانضمام: | edsdoj.61fb72393f95426b8e92e43405f0429c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20417314 |
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| DOI: | 10.1177/2041731420968030 |