Linear Accelerator-Based Stereotactic Radiotherapy for Low-Grade Meningiomas: Improved Local Control With Hypofractionation
| العنوان: | Linear Accelerator-Based Stereotactic Radiotherapy for Low-Grade Meningiomas: Improved Local Control With Hypofractionation |
|---|---|
| المؤلفون: | Stephen Karlovits, Shaakir Hasan, Stephen Abel, Russell Fuhrer, Sidney Anderson, Richard Williamson, Rodney E. Wegner |
| المصدر: | Journal of Central Nervous System Disease, Vol 11 (2019) Journal of Central Nervous System Disease |
| بيانات النشر: | SAGE Publishing, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | High rate, Surgical resection, medicine.medical_specialty, hypofractionated, business.industry, medicine.medical_treatment, stereotactic radiosurgery, Who grade, medicine.disease, meningioma, Radiosurgery, lcsh:RC346-429, Benign tumor, Resection, Meningioma, Stereotactic radiotherapy, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, medicine, Radiology, business, 030217 neurology & neurosurgery, lcsh:Neurology. Diseases of the nervous system, Original Research |
| الوصف: | Background and purpose: Meningioma is a common type of benign tumor that can be managed in several ways, ranging from close observation, surgical resection, and various types of radiation. We present here results from a 10-year experience treating meningiomas with a hypofractionated approach. Materials and methods: We reviewed the charts of 56 patients treated with stereotactic radiosurgery (SRS) or hypofractionated stereotactic radiotherapy (SRT) from 2008 to 2017. A total of 46 (82%) patients had WHO Grade 1 disease and 10 (18%) had Grade 2. Outcomes that were analyzed included local control rates and the rate and grade of any reported toxicity. Results: A total of 38 women and 18 men underwent SRS to a median dose of 15 Gy (n = 24) or hypofractionated SRT with a median dose of 25 Gy in five fractions (n = 34). Of the 56 patients, 22 had surgery before receiving treatment. The median follow-up was 36 (6-110) months. Local control at 2 and 5 years for all patients was 90% and 88%, respectively. Comparing fractionated to single-fraction treatment, there was improved local control with fractionation (91% vs 80% local control at 2 years, P = .009). There was one episode of late radionecrosis on imaging with associated symptoms after single-fraction treatment and one patient requiring resection of meningioma related to worsening symptoms (and local recurrence) after five-fraction SRT. Conclusions: This study provides further evidence for high rates of local control and minimal toxicity using a hypofractionated SRT approach, with improvement in local control through use of hypofractionation. |
| اللغة: | English |
| تدمد: | 1179-5735 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4342b18e177ddc1789cf5080596842ffTest https://doaj.org/article/7695943a8b5c450686e2a1c40feb0675Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4342b18e177ddc1789cf5080596842ff |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 11795735 |
|---|