دورية أكاديمية
The role of S100B protein, neuron-specific enolase, and glial fibrillary acidic protein in the evaluation of hypoxic brain injury in acute carbon monoxide poisoning
| العنوان: | The role of S100B protein, neuron-specific enolase, and glial fibrillary acidic protein in the evaluation of hypoxic brain injury in acute carbon monoxide poisoning |
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| المؤلفون: | Akdemir, H. U., Yardan, T., Kati, C., Duran, L., Alacam, H., Yavuz, Y., Okuyucu, A. |
| المساهمون: | Ondokuz Mayıs Üniversitesi |
| بيانات النشر: | Sage Publications Ltd |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | S100B protein, neuron-specific enolase, glial fibrillary acidic protein, carbon monoxide poisoning, hypoxic brain injury |
| الوصف: | WOS: 000344349600003 ; PubMed: 24505052 ; The main purpose of this study was to assess the role of S100B protein, neuron-specific enolase (NSE), and glial fibrillary acidic protein (GFAP) in the evaluation of hypoxic brain injury in acute carbon monoxide (CO)-poisoned patients. This cross-sectional study was conducted among the patients with acute CO poisoning who referred to the emergency department in a 1-year period. Serum levels of S100B protein, NSE, and GFAP were determined on admission. A total of 55 CO-poisoned patients (mean age +/- standard deviation, 45 +/- 20.3 years; 60% women) were included in the study. The control group consisted of 25 healthy adults. The patients were divided into two groups according to whether they were conscious or unconscious. The serum levels of S100B, NSE, and GFAP were higher in patients than that in the control group. There was no significant difference between unconscious and conscious patients with respect to these markers. There was a statistically significant difference between the conscious and unconscious patients and the control group in terms of S100B and NSE levels. There was also a statistically significant difference between the unconscious patients and the control group in terms of GFAP levels. Increased serum S100B, NSE, and GFAP levels are associated with acute CO poisoning. These biomarkers can be useful in assessing the clinical status of patients with CO poisoning. ; Scientific Research Council of Ondokuz Mayis UniversityOndokuz Mayis University [PYO.TIP.1901.12.036] ; This study was supported by the Scientific Research Council of Ondokuz Mayis University with the number of PYO.TIP.1901.12.036. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0960-3271 1477-0903 |
| العلاقة: | Human & Experimental Toxicology; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.1177/0960327114521049Test; https://hdl.handle.net/20.500.12712/14906Test; 33; 11; 1113; 1120 |
| DOI: | 10.1177/0960327114521049 |
| الإتاحة: | https://doi.org/20.500.12712/14906Test https://doi.org/10.1177/0960327114521049Test https://hdl.handle.net/20.500.12712/14906Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.8B9D527B |
| قاعدة البيانات: | BASE |
| تدمد: | 09603271 14770903 |
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| DOI: | 10.1177/0960327114521049 |