دورية أكاديمية
Dimethyl fumarate selectively reduces memory T cells in multiple sclerosis patients
| العنوان: | Dimethyl fumarate selectively reduces memory T cells in multiple sclerosis patients |
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| المؤلفون: | Longbrake, Erin E., Ramsbottom, Michael J., Cantoni, Claudia, Ghezzi, Laura, Cross, Anne H., Piccio, Laura |
| المساهمون: | E.E. Longbrake, M.J. Ramsbottom, C. Cantoni, L. Ghezzi, A.H. Cro, L. Piccio |
| بيانات النشر: | SAGE Publications Ltd |
| سنة النشر: | 2016 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Dimethyl fumarate, immunocompetence, immunology, lymphocyte type, lymphopenia, memory T cell, multiple sclerosi, neuroimmunology, relapse, Settore MED/26 - Neurologia |
| الوصف: | Background: Dimethyl fumarate (DMF) alters the phenotype of circulating immune cells and causes lymphopenia in a subpopulation of treated multiple sclerosis (MS) patients. Objective: To phenotypically characterize circulating leukocytes in DMF-treated MS patients. Methods: Cross-sectional observational comparisons of peripheral blood from DMF-treated MS patients (n = 17 lymphopenic and n = 24 non-lymphopenic), untreated MS patients (n = 17) and healthy controls (n = 23); immunophenotyped using flow cytometry. Longitudinal samples were analyzed for 13 DMF-treated patients. Results: Lymphopenic DMF-treated patients had significantly fewer circulating CD8+ and CD4+ T cells, CD56dim natural killer (NK) cells, CD19+ B cells and plasmacytoid dendritic cells when compared to controls. CXCR3+ and CCR6+ expression was disproportionately reduced among CD4+ T cells, while the proportion of T-regulatory (T-reg) cells was unchanged. DMF did not affect circulating CD56hi NKcells, monocytes or myeloid dendritic cells. Whether lymphopenic or not, DMF-treated patients had a lower proportion of circulating central and effector memory T cells and concomitant expansion of naïve T cells compared to the controls. Conclusions: DMF shifts the immunophenotypes of circulating T cells, causing a reduction of memory cells and a relative expansion of naïve cells, regardless of the absolute lymphocyte count. This may represent one mechanism of action of the drug. Lymphopenic patients had a disproportionate loss of CD8+ T-cells, which may affect their immunocompetence. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/26459150; info:eu-repo/semantics/altIdentifier/wos/WOS:000380117000014; volume:22; issue:8; firstpage:1061; lastpage:1070; numberofpages:10; journal:MULTIPLE SCLEROSIS; http://hdl.handle.net/2434/598230Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84978083374 |
| DOI: | 10.1177/1352458515608961 |
| الإتاحة: | https://doi.org/10.1177/1352458515608961Test http://hdl.handle.net/2434/598230Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.A572F9FC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/1352458515608961 |
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