التفاصيل البيبلوغرافية
| العنوان: |
Sodium Dichloroacetate Pharmacological Effect as Related to Na–K–2Cl Cotransporter Inhibition in Rats. |
| المؤلفون: |
Stanevičiūtė, Jūratė1, Juknevičienė, Milda1, Palubinskienė, Jolita1, Balnytė, Ingrida1, Valančiūtė, Angelija1, Vosyliūtė, Rūta1, Sužiedėlis, Kęstutis2, Lesauskaitė, Vaiva3, Stakišaitis, Donatas1,2 donatas.stakisaitis@lsmuni.lt |
| المصدر: |
Dose-Response. Oct-Dec2018, Vol. 16 Issue 4, p1-1. 1p. |
| مصطلحات موضوعية: |
*LABORATORY rats, *DIURESIS, *URINE, *IMMUNOHISTOCHEMISTRY, *RNA, *THYMUS |
| مستخلص: |
The study objective was to investigate a possible sodium dichloroacetate (DCA) pharmacological mechanism causing an increase in diuresis in rats. The aim was to define characteristics of 24-hour urinary Na+, K+, Cl−, Ca2+, and Mg2+ excretion in Wistar male rats and to evaluate effect of a single-dose DCA and repeated DCA dosage on diuresis. Six control and 6 DCA-treated male rats aged 5 to weeks after a single DCA dose and repeated dosage were tested. The single DCA dose treatment caused a significantly higher 24-hour diuresis when compared to control (P < .05), and it was related to increased Cl−, Na+, and K+ urine excretion and a significant increase in Ca2+ and Mg2+ excretion (P < .05); after the repeated 4-week DCA dosage, the diuresis was not increased, but the excretion of the Na+, Cl−, Ca2+, and Mg2+ ions was significantly higher. Kidney immunohistochemistry has revealed that DCA continuous treatment results in an increase in the size of Henle loop thick ascending limb epithelial cells (P < .001). The study results show a significantly reduced RNA expression of Na-K-2Cl co-transporter (NKCC1) in thymus of 4-week DCA-treated rats (P < .03). The study data have indicated a possible mechanism of such pharmacological effect to be NKCC inhibition. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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