التفاصيل البيبلوغرافية
| العنوان: |
Low Incidence of Symptomatic Thrombotic Events in Adult Patients Hospitalized with Coronavirus 19: A Retrospective Cohort Study. |
| المؤلفون: |
Vallone, Marcelo G., Vazquez, Carolina, Chuliber, Fernando A., Privitera, Verónica, Ferraris, Augusto, Cantarella, Ramiro F., Indo, María F., Sanchez Thomas, Diego M., Peuchot, Verónica A., Vazquez, Fernando J. |
| المصدر: |
Clinical & Applied Thrombosis/Hemostasis; 2021, Vol. 27, p1-8, 8p |
| مصطلحات موضوعية: |
STROKE, VENOUS thrombosis, ACUTE coronary syndrome, COVID-19, COHORT analysis, ADULTS |
| مستخلص: |
Background: Since the beginning of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) pandemic, there have been many reports of increased incidence of venous thromboembolism and arterial events as a complication. Objective: To determine the incidence of symptomatic thrombotic events (TEs) in patients hospitalized for SARS-CoV2 disease (coronavirus 19 [Covid-19]). Methods: A retrospective single-center cohort study with adult patients with a positive reverse transcriptase-polymerase chain reaction (rt-PCR) for SARS-CoV2, included from the date of diagnosis of Covid-19 and followed for 90 days or until death. Results: A total of 1621 patients were included in this study. The median age was 73 years (interquartile range25th-75th [IQR] 53-87 years) and 57% (913) were female. Overall mortality was 21.6% (348). The overall incidence of symptomatic TEs within 90 days of diagnosis was 1.8% (30 of 1621) occurring in 28 patients, including an incidence of pulmonary embolism of 0.9% (15, 95% confidence interval [CI] 0.60%-1.6%), deep venous thrombosis of 0.61% (10, 95% CI 0.2%-1%), ischemic stroke of 0.25% (4, 95% CI 0.09%-0.65%), and ischemic arterial events of 0.06% (1, 95% CI 0.008%-0.43%). No acute coronary syndrome events were recorded. The incidence of symptomatic TEs was significantly lower in the general ward than in intensive care units (1.2% vs 5.7%; p <.001). The median time since positive rt-PCR for SARS-CoV2 to symptomatic TE was 22.5 days (IQR 19-43 days). There was no significant difference in the proportion of patients receiving (53.6%) and not receiving thromboprophylaxis (66.5%) and the development of TEs. Conclusion: The overall incidence of symptomatic TEs among these patients was lower than the incidence previously reported. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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