التفاصيل البيبلوغرافية
| العنوان: |
Aquaporin-4 IgG antibody-related disorders in patients with juvenile systemic lupus erythematosus. |
| المؤلفون: |
Moraitis, E, Stathopoulos, Y, Hong, Y, Al-Obaidi, M, Mankad, K, Hacohen, Y, Sen, D, Hemingway, C, Eleftheriou, D |
| المصدر: |
Lupus; 2019, Vol. 28 Issue 10, p1243-1249, 7p, 1 Black and White Photograph, 2 Charts |
| مصطلحات موضوعية: |
SYSTEMIC lupus erythematosus, TRANSVERSE myelitis, OPTIC neuritis, FISHER exact test |
| مستخلص: |
Objective: The aim of this study was to: (a) screen a large group of unselected patients with juvenile systemic lupus erythematosus for anti-aquaporin 4 antibodies (AQP4-Ab); (b) identify clinical and laboratory predictors of the presence of AQP4-Ab positivity in juvenile systemic lupus erythematosus. Methods: Sera from 90 patients with juvenile systemic lupus erythematosus were tested for the presence of AQP4-Ab using a cell-based assay. Demographics, clinical and immunological features, treatment received were summarized. Fisher's exact test was used to identify clinical predictors of positivity for AQP4-Ab. Results: Five of 90 (5.5%) patients tested positive for AQP4-Ab, all of which had neurological involvement, mainly transverse myelitis and optic neuritis. AQP4-Ab-positive patients were more likely to have neurological symptoms (P = 0.002), less likely to experience dermatological manifestations (P = 0.045), and less likely to have detectable anti-dsDNA antibodies (P = 0.022). These patients were also more likely to have received anti-epileptic (P = 0.023) and anti-coagulant (P = 0.007) drugs. Conclusions: The findings of this study indicate that some patients with juvenile systemic lupus erythematosus develop antibodies against aquaporin-4 and may be at risk of developing a neurological clinical phenotype. We suggest that all juvenile systemic lupus erythematosus patients should be systematically screened for the presence of AQP4-Ab and this may help identify a high risk for neurological involvement in juvenile systemic lupus erythematosus. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
