التفاصيل البيبلوغرافية
| العنوان: |
15O Radioactivity Clearance is Faster After Intracarotid Bolus Injection of 15O-Labeled Oxyhemoglobin Than After 15O-Water Injection. |
| المؤلفون: |
Chie Seki1 |
| المصدر: |
Journal of Cerebral Blood Flow & Metabolism. Jul2003, Vol. 23 Issue 7, p838. 7p. |
| مصطلحات موضوعية: |
*BRAIN, *TISSUES, *OXYGEN in the body, *OXYHEMOGLOBIN, *CEREBRAL dominance testing |
| مستخلص: |
The authors tested the hypothesis that the oxygen content of brain tissue is negligible by injecting an intracarotid bolus of 15O-labeled tracer into rats. Under the hypothesis, the clearance rates of 15O radioactivity from the brain after injections of both 15O-labeled water (H215O) and 15O-labeled oxyhemoglobin (HbO15O) should be identical. However, the logarithmic slope of the 15O radioactivity curve after HbO15O injection (0.494 ± 0.071 min-1) was steeper than that after H215O injection (0.406 ± 0.038 min-1) (P<0.001, n = 13), where the time range used in the comparison was between 60 and 120 seconds after the injection. A possible interpretation of this result is that nonmetabolized O15O may dwell in the brain tissue for a finite period of time before it is eventually metabolized or returned to the blood stream unaltered. These findings contradict assumptions made by models currently used to measure cerebral oxygen metabolism. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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