التفاصيل البيبلوغرافية
| العنوان: |
Lipid peroxidation and changes in major antioxidant markers in copper quinolate fungicide-exposed rats. |
| المؤلفون: |
Baali, B, Kirane-Amrani, L, Tichati, L, Soual, R, Ouali, K |
| المصدر: |
Toxicology & Industrial Health; Nov2023, Vol. 39 Issue 11, p664-678, 15p |
| مصطلحات موضوعية: |
ASPARTATE aminotransferase, COPPER, ALKALINE phosphatase, TOXICITY testing, ALBUMINS, LIPIDS, LACTATE dehydrogenase, ALANINE aminotransferase |
| مستخلص: |
The present study investigated the toxic effects of sub-chronic exposure to copper quinolate (CuQ) fungicide on liver and kidney function. Twenty-four adult male Wistar rats were equally divided into a control group, and three treated groups received, respectively, by oral gavage, three increasing doses of CuQ: 47; 67.1; and 94 mg/kg b.w corresponding, respectively, LD50/100, LD50/70, and LD50/50 daily for 8 weeks. CuQ resulted in a significant increase in the serum enzymatic activity of aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and the serum levels of urea, creatinine, uric acid, and malondialdehyde, along with a marked decrease in alanine aminotransferase (ALT) activity, and the contents of total protein and albumin compared to those of the control group. Furthermore, glutathione content and the enzymatic activity of superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), and glutathione peroxidase (GPx) decreased significantly in a dose-dependent manner with respect to CuQ. The adverse effects of CuO were supported by the histopathological evaluations of liver and kidney tissues. Conclusively, sub-chronic CuQ exposure was shown to induce kidney and liver oxidative damage and dysfunction. [ABSTRACT FROM AUTHOR] |
|
Copyright of Toxicology & Industrial Health is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
