دورية أكاديمية
Impaired Functional Connectivity Unmasked by Simple Repetitive Motor Task in Early Relapsing-Remitting Multiple Sclerosis.
| العنوان: | Impaired Functional Connectivity Unmasked by Simple Repetitive Motor Task in Early Relapsing-Remitting Multiple Sclerosis. |
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| المؤلفون: | PETSAS, NIKOLAOS, TOMASSINI, VALENTINA, Filippini N, SBARDELLA, EMILIA, TONA, FRANCESCA, Piattella MC, POZZILLI, Carlo, Wise RG, PANTANO, Patrizia |
| المساهمون: | Petsas, Nikolao, Tomassini, Valentina, Filippini, N, Sbardella, Emilia, Tona, Francesca, Piattella, Mc, Pozzilli, Carlo, Wise, Rg, Pantano, Patrizia |
| بيانات النشر: | SAGE Publications Inc. |
| سنة النشر: | 2014 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | fMRI, functional connectivity, motor task, multiple sclerosi, resting state, Adult, Brain, Brain Mapping, Diffusion Tensor Imaging, Female, Gray Matter, Human, Magnetic Resonance Imaging, Male, Motor Activity, Multiple Sclerosis, Relapsing-Remitting, Neural Pathway, Regression Analysi, Rest, Rehabilitation, Neurology, Neurology (clinical) |
| الوصف: | Resting brain activity can be modulated by motor tasks to adapt to function. In multiple sclerosis (MS) patients, altered resting-state functional connectivity (RS-FC) has been reported and associated with impaired function and disability; little is known on how RS-FC is modulated by a simple repetitive motor task. OBJECTIVE: To assess changes in RS-FC in early relapsing-remitting MS (RRMS) patients associated with repetitive thumb flexions (RTFs). METHODS: A total of 20 right-handed patients with early RRMS and 14 healthy controls underwent a resting functional magnetic resonance imaging (fMRI) scan, before and after 25 minutes of alternate 30-s blocks of right RTF and rest. Dual-regression analysis of resting fMRI data followed the independent component analysis. Individual spatial maps of coherence between brain areas for 2 networks of interest, sensorimotor and cerebellar, were compared at the group level and correlated with measures of both clinical impairment and brain damage. RESULTS: Significant RTF-induced differences in RS-FC were observed between groups in the cerebellar network because of increased RS-FC in patients but not in controls. In the sensorimotor network, the RS-FC after RTF increased in both groups, with no significant between-group differences. The sensorimotor and the cerebellar RS-FC were intercorrelated only in patients and only after the RTF. The sensorimotor RS-FC increase in patients correlated with structural MRI alterations. CONCLUSIONS: Our study unmasked RS-FC changes of motor-related networks occurring after a simple repetitive motor task in early RRMS patients only. Evaluation of altered RSN dynamics might prove useful for anticipating neuroplasticity and for MRI-informed neurorehabilitation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/25416740; info:eu-repo/semantics/altIdentifier/wos/WOS:000358313600007; volume:29; issue:6; firstpage:---; lastpage:---; numberofpages:9; journal:NEUROREHABILITATION AND NEURAL REPAIR; http://hdl.handle.net/11573/652832Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84936946705 |
| DOI: | 10.1177/1545968314558600 |
| الإتاحة: | https://doi.org/10.1177/1545968314558600Test http://hdl.handle.net/11573/652832Test |
| رقم الانضمام: | edsbas.E08AE3BE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/1545968314558600 |
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