التفاصيل البيبلوغرافية
| العنوان: |
Gallic acid protects against isoproterenol-induced cardiotoxicity in rats. |
| المؤلفون: |
Shackebaei, Dareuosh, Hesari, Mahvash, Ramezani-Aliakbari, Soudabeh, Hoseinkhani, Zohreh, Ramezani-Aliakbari, Fatemeh |
| المصدر: |
Human & Experimental Toxicology; Jan-Dec2022, Vol. 41, p1-10, 10p |
| مصطلحات موضوعية: |
CARDIOTOXICITY, PHENOLS, ISOPROTERENOL, ANIMAL experimentation, CREATINE kinase, SUPEROXIDE dismutase, RATS, COMPARATIVE studies, ISOENZYMES, GENE expression, TREATMENT effectiveness, LACTATE dehydrogenase, RESEARCH funding, STATISTICAL sampling, HEMODYNAMICS |
| مستخلص: |
Background: Gallic acid (GA) is a polyphenolic agent with interesting pharmacological impacts on the cardiovascular system. Objective: The present study purposed to study the protective effects of GA at 25 and 50 mg/kg against isoproterenol (ISO)-induced cardiac damage in ischemia/reperfusion (I/R) in rats. Methods: Male Wistar rats were randomly assigned into six groups: Control, Control treated with GA at 25 mg/kg (GA25), Control treated with GA at 50 mg/kg (GA50), Hypertrophic rats induced by ISO (ISO), Hypertrophic rats treated with GA at 25 mg/kg (ISO+GA25), and Hypertrophic rats treated with GA at 50 mg/kg (ISO+GA50). Heart isolation was performed to induce a cardiac I/R injury model. Cardiac hemodynamic parameters were recorded. Serum Lactate Dehydrogenase (LDH) and Creatine Kinase-MB (CK-MB) and cardiac Superoxide dismutases (SOD) levels were evaluated. The gene expression of Sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) was assessed. Results: We found that GA at 50 mg/kg was significantly increased cardiac function at post I/R period in ISO-induced hypertrophic hearts. Moreover, it suppressed cardiac hypertrophy, the serum LDH and CK-MB levels in ISO injected rats. Administration of GA at 50 mg/kg was significantly increased SOD level and SERCA2a gene expression in the hypertrophic hearts. Conclusion: GA at 50 mg/kg could improve cardiac performance possibly by increasing antioxidant defense enzymes, reducing cell damage, and enhancing SERCA2a gene expression in hypertrophic heart induced by ISO in I/R injury conditions. [ABSTRACT FROM AUTHOR] |
|
Copyright of Human & Experimental Toxicology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
