التفاصيل البيبلوغرافية
| العنوان: |
Safety and Efficacy of Repeat Open-Label AbobotulinumtoxinA Treatment in Pediatric Cerebral Palsy. |
| المؤلفون: |
Delgado, Mauricio R., Bonikowski, Marcin, Carranza, Jorge, Dabrowski, Edward, Matthews, Dennis, Russman, Barry, Tilton, Ann, Velez, Juan Carlos, Grandoulier, Anne-Sophie, Picaut, Philippe |
| المصدر: |
Journal of Child Neurology; Nov2017, Vol. 32 Issue 13, p1058-1064, 7p |
| مصطلحات موضوعية: |
CEREBRAL palsy treatment, PEDIATRIC neurology, DRUG efficacy, CLINICAL trials, HEALTH outcome assessment, CEREBRAL palsy, CHILDREN'S health, DEVELOPMENTAL disabilities |
| مستخلص: |
This was a prospective, repeat-treatment, open-label study (NCT01251380) of abobotulinumtoxinA for the management of lower limb spasticity in children who had completed a double-blind study. Children (2-17 years) received injections into the gastrocnemius-soleus complex, and other distal and proximal muscles as required (maximum total dose per injection cycle: 30 U/ kg or 1000U). A total of 216 of the 241 double-blind patients entered the extension study and 207 received ≥1 open label injection into the gastrocnemius-soleus; 17-24% of patients also had injections into the hamstrings. The most frequent adverse events were related to common childhood infections and the most frequent treatment-related adverse event was injection site pain (n = 10). There was no evidence of a cumulative effect on adverse events. Sustained significant clinical improvements in muscle tone (Modified Ashworth Scale), spasticity (Tardieu Scale), overall clinical benefit (Physicians Global Assessment), and goal attainment (Goal Attainment Scale) were also observed across treatment cycles. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Child Neurology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
