التفاصيل البيبلوغرافية
| العنوان: |
Intracranial structural alteration predicts treatment outcome in patients with spontaneous intracranial hypotension. |
| المؤلفون: |
Choi, Hanna1, Lee, Mi Ji2, Choi, Hyun Ah2, Cha, Jihoon3, Chung, Chin-Sang2 cspaul@naver.com |
| المصدر: |
Cephalalgia. Feb2018, Vol. 38 Issue 2, p323-331. 9p. 2 Black and White Photographs, 3 Charts, 1 Graph. |
| مصطلحات موضوعية: |
*INTRACRANIAL hypertension, *EPIDURAL blood patch, *TREATMENT effectiveness, *RETROSPECTIVE studies, *MULTIVARIATE analysis, *BRAIN disease treatment, *BRAIN diseases, *COMPARATIVE studies, *MAGNETIC resonance imaging, *RESEARCH methodology, *MEDICAL cooperation, *RESEARCH, *EVALUATION research |
| مستخلص: |
Background Intracranial structural dislocation in spontaneous intracranial hypotension (SIH) can be measured by various intracranial angles and distances. We aimed to identify the clinical significance of structural dislocation in relation to treatment outcome in patients with SIH. Methods In this retrospective analysis, we identified patients with SIH who received an epidural blood patch (EBP) at Samsung Medical Center from January 2005 to March 2015. Structural dislocation in pretreatment MRIs of SIH patients was assessed by measuring tonsillar herniation, mamillopontine distance, the angle between the vein of Galen and straight sinus (vG/SS angle), the pontomesencephalic angle, and the lateral ventricular angle. After the first EBP, poor response was defined as the persistence of symptoms that prompted a repeat EBP. Results Out of the 95 patients included, 31 (32.6%) showed poor response. Among the radiological markers of structural dislocation, the vG/SS angle was associated with poor response (49.82 ± 16.40° vs 66.58 ± 26.08°, p = 0.002). Among clinical variables, premorbid migraine ( p = 0.036) was related to poor response. In multivariate analysis, reduced vG/SS angle was independently associated with poor response (OR 1.04 [95% CI 1.01 - 1.07] per 1° decrease, p = 0.006). In 23 patients who underwent MRI after successful treatment, the vG/SS angle significantly increased after the EBP ( p < 0.001, by paired t-test), while two patients with aggravation or recurrence showed a further reduction of their vG/SS angles. Conclusions Intracranial structural dislocation, measured by the vG/SS angle, is associated with poor response to the first EBP in patients with SIH. Successful treatment can reverse the structural dislocation. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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