Levosimendan as rescue therapy in low output syndrome after cardiac surgery: effects and predictors of outcome
| العنوان: | Levosimendan as rescue therapy in low output syndrome after cardiac surgery: effects and predictors of outcome |
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| المؤلفون: | Angela Kornberger, Marion Weis, Martin Oberhoffer, Felix Kur, Christian-Friedrich Vahl, Florian Weis, Andres Beiras-Fernandez |
| المصدر: | The Journal of International Medical Research Journal of International Medical Research, Vol 47 (2019) |
| بيانات النشر: | SAGE Publications, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Medicine (General), medicine.medical_specialty, Postoperative low cardiac output syndrome, Cardiotonic Agents, calcium sensitizers, 030204 cardiovascular system & hematology, Biochemistry, Calcium sensitizer, 03 medical and health sciences, levosimendan, R5-920, 0302 clinical medicine, Postoperative Complications, Rescue therapy, Internal medicine, Medicine, Humans, In patient, 030212 general & internal medicine, Cardiac Output, Cardiac Surgical Procedures, Special Issue: Cardiothoracic Critical Care, Simendan, Aged, Retrospective Studies, Low output syndrome, business.industry, Biochemistry (medical), outcome predictors, Cell Biology, General Medicine, Levosimendan, treatment algorithm, Middle Aged, Prognosis, Cardiac surgery, Survival Rate, Low cardiac output syndrome, Cardiology, Female, business, cardiac surgery, medicine.drug, Follow-Up Studies |
| الوصف: | Objectives Calcium sensitizers have been shown to improve outcomes in patients with low cardiac output syndrome (LCOS) after cardiac surgery. We assessed the effects of levosimendan on LCOS in cardiac surgical patients to identify outcome predictors. Methods A total of 106 patients in whom LCOS persisted despite conventional therapy additionally received 0.1 µg/kg/min of levosimendan for 24 hours according to a defined treatment algorithm. Baseline and treatment data as well as hemodynamic and outcome parameters were compared between survivors and nonsurvivors, and a multivariate correlation and regression tree analysis was implemented. Results The ejection fraction significantly increased from 27% ± 4% to 38% ± 8% within 24 hours and to 45% ± 10% within 48 hours of starting levosimendan. These changes were accompanied by a significant increase in cardiac output from 5.2 ± 0.6 to 6.2 ± 0.7 L/min within 24 hours and significant dose reductions in vasopressors and inotropes. In contrast to nonsurvivors, survivors’ need for inotropic support decreased after the addition of levosimendan to the therapy. Conclusion In our patients, all of whom were treated according to the same algorithm, the response to levosimendan in terms of the post-levosimendan need for inotropes and vasopressors predicted survival. |
| اللغة: | English |
| تدمد: | 1473-2300 0300-0605 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0835ca9015db7c8047772d0c8cc21d72Test http://europepmc.org/articles/PMC6726822Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0835ca9015db7c8047772d0c8cc21d72 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14732300 03000605 |
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