Evaluation of Combined Cancer Markers With Lactate Dehydrogenase and Application of Machine Learning Algorithms for Differentiating Benign Disease From Malignant Ovarian Cancer
| العنوان: | Evaluation of Combined Cancer Markers With Lactate Dehydrogenase and Application of Machine Learning Algorithms for Differentiating Benign Disease From Malignant Ovarian Cancer |
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| المؤلفون: | Seri Jeong, Dae-Soon Son, Minseob Cho, Nuri Lee, Wonkeun Song, Saeam Shin, Sung-Ho Park, Dong Jin Lee, Min-Jeong Park |
| المصدر: | Cancer Control : Journal of the Moffitt Cancer Center Cancer Control, Vol 28 (2021) |
| بيانات النشر: | SAGE Publications, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, endocrine system diseases, Neutrophils, Diagnosis, Differential, Machine Learning, Leukocyte Count, WAP Four-Disulfide Core Domain Protein 2, neutrophil-to-lymphocyte ratio, Biomarkers, Tumor, human epididymis protein 4, Humans, Original Research Article, Lymphocytes, RC254-282, Early Detection of Cancer, Ovarian Neoplasms, L-Lactate Dehydrogenase, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Membrane Proteins, lactate dehydrogenase, Hematology, General Medicine, Middle Aged, cancer antigen 125, ovarian cancer, Oncology, ROC Curve, CA-125 Antigen, Female |
| الوصف: | Background The differential diagnosis of ovarian cancer is important, and there has been ongoing research to identify biomarkers with higher performance. This study aimed to evaluate the diagnostic utility of combinations of cancer markers classified by machine learning algorithms in patients with early stage ovarian cancer, which has rarely been reported. Methods In total, 730 serum samples were assayed for lactate dehydrogenase (LD), neutrophil-to-lymphocyte ratio (NLR), human epididymis protein 4 (HE4), cancer antigen 125 (CA125), and risk of ovarian malignancy algorithm (ROMA). Among them, 53 were diagnosed with early stage ovarian cancer, and the remaining 677 were diagnosed with benign disease. Results The areas under the receiver operating characteristic curves (ROC-AUCs) of the ROMA, HE4, CA125, LD, and NLR for discriminating ovarian cancer from non-cancerous disease were .707, .680, .643, .657, and .624, respectively. ROC-AUC of the combination of ROMA and LD (.709) was similar to that of single ROMA in the total population. In the postmenopausal group, ROC-AUCs of HE4 and CA125 combined with LD presented the highest value (.718). When machine learning algorithms were applied to ROMA combined with LD, the ROC-AUC of random forest was higher than that of other applied algorithms in the total population (.757), showing acceptable performance. Conclusion Our data suggest that the combinations of ovarian cancer-specific markers with LD classified by random forest may be a useful tool for predicting ovarian cancer, particularly in clinical settings, due to easy accessibility and cost-effectiveness. Application of an optimal combination of cancer markers and algorithms would facilitate appropriate management of ovarian cancer patients. |
| اللغة: | English |
| تدمد: | 1526-2359 1073-2748 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3178bc27600547e2157068f103f7d00fTest http://europepmc.org/articles/PMC8704186Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3178bc27600547e2157068f103f7d00f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15262359 10732748 |
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