CD200Fc Improves Neurological Function by Protecting the Blood–brain Barrier after Intracerebral Hemorrhage
| العنوان: | CD200Fc Improves Neurological Function by Protecting the Blood–brain Barrier after Intracerebral Hemorrhage |
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| المؤلفون: | Xiao-di Hao, Zachary D. Travis, Lu-Sha Tong, Chen-Sheng Le, Hao-Ran Lin, Jia-Wen Li, Jia-Wei Zhong, Yi-Ting Zhou, Feng Gao |
| المصدر: | Cell Transplantation Cell Transplantation, Vol 28 (2019) |
| بيانات النشر: | SAGE Publications, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Neurological function, Autologous blood, Central nervous system, Biomedical Engineering, Pharmacology, blood–brain barrier, Blood–brain barrier, Mice, 03 medical and health sciences, 0302 clinical medicine, Immune system, CD200R1, Antigens, CD, Orexin Receptors, medicine, Animals, cardiovascular diseases, Cerebral Hemorrhage, Intracerebral hemorrhage, Transplantation, business.industry, Treatment options, Original Articles, Cell Biology, medicine.disease, intracerebral hemorrhage, Immunoglobulin Fc Fragments, nervous system diseases, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, Blood-Brain Barrier, CD200, Medicine, business, Bbb permeability, 030217 neurology & neurosurgery |
| الوصف: | CD200 is widely distributed in the central nervous system and plays an essential role in the immune response in neurological diseases. However, little is currently known about the effects of CD200 signaling on the blood–brain barrier (BBB) function after intracerebral hemorrhage (ICH). In this study, the role of CD200 during ICH in an autologous blood induced mouse ICH model was investigated. Following ICH, critical protein expression, BBB permeability, and neurological function were measured with or without CD200Fc administration. Our results showed that both the expression of CD200 and CD200R1 decreased after ICH and administration of CD200Fc attenuated BBB leakage and improved neurological functions. In conclusion, our work demonstrated that CD200Fc might be a potential treatment option for ICH by protecting the BBB and improving functional outcomes. |
| تدمد: | 1555-3892 0963-6897 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae0d0c2976b14e6bd0bfc2b56e47d0eTest https://doi.org/10.1177/0963689719857655Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....eae0d0c2976b14e6bd0bfc2b56e47d0e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15553892 09636897 |
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