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1دورية أكاديمية
المصدر: Materials Science and Technology ; volume 29, issue 6, page 710-714 ; ISSN 0267-0836 1743-2847
الوصف: Microstructural evolution and mechanical responses of Mg–3Al–1Zn (AZ31) sheet processed by the asymmetric extrusion (ASE) and conventional extrusion (CE) are examined. Mechanical properties of ASE sheets were remarkably enhanced compared with CE samples. This is attributed to the subdivision of the asymmetric extrusion die along the flow passage equipped with a chamfer on one side, which would trigger the angular spread of the basal texture by introducing an asymmetry shear deformation. Moreover, subsequent annealed ASE specimens show a significant weakening of the basal texture and a combination of the superior stretch formability.
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2دورية أكاديمية
المصدر: Journal of International Medical Research ; volume 37, issue 2, page 491-502 ; ISSN 0300-0605 1473-2300
الوصف: Pre-exposure to lipopolysaccharide (LPS) leads to hyposensitivity to secondary LPS stimulation, known as endotoxin tolerance. The role of macrophage scavenger receptor-A (SR-A) in endotoxin tolerance is unknown. In this study, LPS was shown to induce SR-A expression in the mouse macrophage cell line, RAW264.7, in dose- and time-dependent manners, which correlated with inflammatory cytokine suppression in RAW264.7 on secondary LPS stimulation. Over-expression of SR-A in RAW264.7 suppressed tumour necrosis factor (TNF)-α release and nuclear factor (NF)-kB activation, demonstrating the involvement of SR-A in endotoxin tolerance. LPS-pre-treated RAW264.7 cells could bind and internalize more fluorescein isothiocyanate (FITC)-LPS than untreated cells and both the SR-A ligand, fucoidan, and anti-SR-A 2F8 antibodies completely suppressed LPS-induced binding and internalization of FITC-LPS by RAW264.7. LPS-induced SR-A expression on RAW264.7 was completely suppressed by the p38-specific inhibitor, SB203580, but not by inhibition of toll-like receptor 4 (TLR4) signalling with MTS510, demonstrating that p38- but not TLR4-dependent up-regulation of SR-A was involved in endotoxin tolerance through binding and internalization of LPS.
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3دورية أكاديمية
المصدر: International Journal of STD & AIDS ; volume 20, issue 3, page 211-212 ; ISSN 0956-4624 1758-1052
مصطلحات موضوعية: Infectious Diseases, Pharmacology (medical), Public Health, Environmental and Occupational Health, Dermatology
الوصف: Summary As the incidence of genital warts increases, warts arising in the mouth, throat and other sites can occasionally be seen. Condyloma gigantea in genital sites are often reported, but literature on genital warts in transsexuals is rare. We present a case of C. gigantea in a 23-year-old male-to-female transsexual, whose warts arose on the transplanted skin of a neovagina and in the perianal region. We conclude that although C. gigantea can occur in transsexuals, the best way to treat it is not clear.
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4دورية أكاديمية
المؤلفون: Connor, T.H., Xiang, Q.
المصدر: Journal of Oncology Pharmacy Practice ; volume 6, issue 3, page 109-114 ; ISSN 1477-092X 1078-1552
مصطلحات موضوعية: Pharmacology (medical), Oncology
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5دورية أكاديمية
المؤلفون: Xiang, Q F, Evans, J R G, Edirisinghe, M J, Blazdell, P F
المصدر: Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture ; volume 211, issue 3, page 211-214 ; ISSN 0954-4054 2041-2975
الوصف: The formulation of a stabilized ceramic ink and the adaptation of a piezoelectric-activated drop- on-demand jet printer with a 65 mm nozzle for the direct solid freeforming of ceramics by multilayer jet printing is reported. The procedure has exciting implications for the miniaturization of ceramic circuits and for the fabrication of solid oxide fuel cells, ordered ceramic composites and small monolithic ceramic components of complex shape.
