An unusual case of primary hepatic lymphoma with dramatic but unsustained response to bendamustine plus rituximab and literature review
| العنوان: | An unusual case of primary hepatic lymphoma with dramatic but unsustained response to bendamustine plus rituximab and literature review |
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| المؤلفون: | Ming-Shiang Wu, Sih-Han Liao, Shan-Chi Yu, Yin-Kai Chen, Ping-Huei Tseng, Hsiu-Po Wang |
| المصدر: | SAGE Open Medical Case Reports SAGE Open Medical Case Reports, Vol 5 (2017) |
| بيانات النشر: | SAGE Publications, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | primary hepatic lymphoma, Oncology, Bendamustine, lcsh:R5-920, medicine.medical_specialty, Unusual case, business.industry, Hemophagocytosis, Case Report, General Medicine, Primary Hepatic Lymphoma, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, medicine, 030211 gastroenterology & hepatology, Rituximab, lcsh:Medicine (General), business, medicine.drug |
| الوصف: | Objectives: Primary hepatic lymphoma is an uncommon cause of hepatic space-occupying lesions. Methods: We describe the case of a 73-year-old man with primary hepatic lymphoma, who presented with a low-grade fever and lower limb weakness which had progressed in the past 2 months. Results: Abdominal ultrasound and computed tomography showed multiple small hepatic tumors. Echo-guided biopsy of the hepatic tumor demonstrated primary hepatic diffuse large B cell lymphoma. Moreover, bone marrow was uninvolved, but the bone marrow smear disclosed hemophagocytosis, which is uncommon in diffuse large B cell lymphoma. Chemotherapy with bendamustine and rituximab treatment was initiated with a dramatic response: hepatic tumors markedly shrank in size shown by follow-up computed tomography and the patient returned to his normal life. Nevertheless, the response was sustained for only 8 months. Finally, the disease resisted further chemotherapy and this patient died of a severe Klebsiella pneumoniae infection. Conclusion: Chemotherapy with bendamustine and rituximab has shown a dramatic, but not durable, response in the present case with old age and multiple comorbidities. |
| تدمد: | 2050-313X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::087c561d46451c14dc88e0686ce66721Test https://doi.org/10.1177/2050313x17709190Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....087c561d46451c14dc88e0686ce66721 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2050313X |
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