التفاصيل البيبلوغرافية
| العنوان: |
Incident Hyperglycaemia among Older Adults with or At-Risk for HIV Infection |
| المؤلفون: |
Polsky, Sarit, Floris-Moore, Michelle, Schoenbaum, Ellie E, Klein, Robert S, Arnsten, Julia H, Howard, Andrea A |
| المصدر: |
Antiviral Therapy ; volume 16, issue 2, page 181-188 ; ISSN 1359-6535 2040-2058 |
| بيانات النشر: |
SAGE Publications |
| سنة النشر: |
2010 |
| مصطلحات موضوعية: |
Infectious Diseases, Pharmacology (medical), Pharmacology |
| الوصف: |
Background HIV infection has been associated with development of prediabetes and diabetes. Optimum screening practices for these disorders in HIV-infected populations remain unclear. Methods We screened 377 adults, with or at-risk for HIV infection, for incident hyperglycaemia (prediabetes or diabetes) using two oral glucose tolerance tests (OGTTs) a median of 18.6 months apart. We determined proportion of incident cases detected by fasting and 120-min plasma glucose levels. Independent predictors of incident hyperglycaemia were identified using logistic regression. Results The baseline OGTT was consistent with diabetes in 7% of participants and with prediabetes in 31%. Among 352 normoglycaemic and prediabetic participants at baseline, 19 (5%) developed diabetes on follow-up. Among participants normoglycaemic at baseline, an additional 38 (16%) developed prediabetes. Overall 52% of incident hyperglycaemia cases were detected by fasting plasma glucose alone, 33% by a 120-min glucose level alone and 15% by both. Factors independently associated with incident hyperglycaemia included age ≥50 years and body mass index ≥30 kg/ m 2 . Neither HIV infection nor highly active antiretroviral therapy (HAART) use were associated with increased risk of diabetes. Conclusions Incident hyperglycaemia is common among older adults with or at-risk for HIV infection. HIV-infected individuals with classic diabetes risk factors should be screened for hyperglycaemia regardless of HAART use. OGTTs might be the preferred screening strategy in HIV-infected individuals at high risk for developing hyperglycaemia. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.3851/imp1711 |
| DOI: |
10.3851/IMP1711 |
| الإتاحة: |
https://doi.org/10.3851/imp1711Test |
| حقوق: |
http://journals.sagepub.com/page/policies/text-and-data-mining-licenseTest |
| رقم الانضمام: |
edsbas.AB444D01 |
| قاعدة البيانات: |
BASE |
