Hydroxycloroquine-induced oxidative stress on sciatic nerve and muscle tissue of rats
| العنوان: | Hydroxycloroquine-induced oxidative stress on sciatic nerve and muscle tissue of rats |
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| المؤلفون: | Abit Aktaş, Rafet Özay, Alevtina Ersoy, Osman Evliyaoglu, ME Uyar, Ertugrul Uzar, Cansel Türkay, Ahmet Z. Burakgazi, Atilla Ilhan, M. B. Ulkay |
| المصدر: | Human & Experimental Toxicology. 31:1066-1073 |
| بيانات النشر: | SAGE Publications, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, Muscle tissue, medicine.medical_specialty, Health, Toxicology and Mutagenesis, Nerve fiber, Nitric Oxide, Toxicology, medicine.disease_cause, Superoxide dismutase, Antimalarials, chemistry.chemical_compound, Atrophy, Malondialdehyde, Internal medicine, medicine, Animals, Rats, Wistar, Muscle, Skeletal, chemistry.chemical_classification, Glutathione Peroxidase, biology, Aryldialkylphosphatase, Superoxide Dismutase, Chemistry, Glutathione peroxidase, General Medicine, Anatomy, medicine.disease, Sciatic Nerve, Rats, Oxidative Stress, Endocrinology, medicine.anatomical_structure, nervous system, biology.protein, Sciatic nerve, Biomarkers, Oxidative stress, Hydroxychloroquine |
| الوصف: | The aim of this study was to investigate the role of hydroxychloroquine (HCQ)-induced oxidative stress on sciatic nerve and muscle tissues of rats. The oxidant/antioxidant parameters in the sciatic nerve and muscle tissues were analyzed, and stereological analysis of the sciatic nerve was performed. Levels of malondialdehyde and nitric oxide in the tissues were significantly higher in the HCQ group than in the control group (p < 0.05). In addition, activities of superoxide dismutase and glutathione peroxidase were found to be significantly higher in the HCQ group than the control group (p < 0.05). There were significant decreases in nerve fiber diameter and myelin sheet thickness in the HCQ group compared with the control group (p < 0.05). These results revealed that HCQ might increase oxidative stress on sciatic nerve and muscle tissues of rats, which may correlate with axonal atrophy in sciatic nerves. |
| تدمد: | 1477-0903 0960-3271 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f605ad76e3f07af502c18a49364f9c81Test https://doi.org/10.1177/0960327111433183Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....f605ad76e3f07af502c18a49364f9c81 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14770903 09603271 |
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