A Consideration for Surgical Management in Select T4b Oral Cavity Squamous Cell Carcinoma
| العنوان: | A Consideration for Surgical Management in Select T4b Oral Cavity Squamous Cell Carcinoma |
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| المؤلفون: | Paul L. Swiecicki, Mark E. Prince, Sarah M. Dermody, Matthew E. Spector, Clifford M. Chang, Michelle Mierzwa, Michelle M. Chen, Steven B. Chinn, Andrew J. Rosko, Francis P. Worden |
| المصدر: | Annals of Otology, Rhinology & Laryngology. 131:609-616 |
| بيانات النشر: | SAGE Publications, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Chemotherapy, Squamous Cell Carcinoma of Head and Neck, business.industry, medicine.medical_treatment, Head and neck cancer, Chemoradiotherapy, Adjuvant, General Medicine, medicine.disease, Otorhinolaryngology, Head and Neck Neoplasms, Internal medicine, Carcinoma, Squamous Cell, medicine, Overall survival, Humans, Mouth Neoplasms, Oral Cavity Squamous Cell Carcinoma, business, Neoplasm Staging, Retrospective Studies |
| الوصف: | Objectives: The role of surgery for conventionally “unresectable” (cT4b) oral cavity squamous cell carcinoma is unclear. We analyzed factors associated with overall survival in cT4b relative to cT4a oral cavity squamous cell carcinoma. Methods: We identified 6830 cT4a and 522 cT4b oral cavity squamous cell carcinoma chemoradiation or surgery + adjuvant therapy patients in the National Cancer Data Base from 2004 to 2016. The main outcome was overall survival. Statistical analysis was performed using chi-squared tests, univariable and multivariable regression analysis. Results: The cT4b group had a higher rate of positive margins (30.4% vs 21.3%, P = .009) and downstaging (41.2% vs 13.1%; P Conclusions: Clinical T4b staging is a poor predictor of pathologic staging given a high rate of downstaging on final pathology. Surgical resection with adjuvant chemoradiation is an option in select cT4b oral cavity squamous cell carcinoma patients. |
| تدمد: | 1943-572X 0003-4894 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f69faa5fec1adfc550f6a7d8c49adcbTest https://doi.org/10.1177/00034894211038213Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....8f69faa5fec1adfc550f6a7d8c49adcb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1943572X 00034894 |
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