Adverse metabolic profiles in a cohort of obese Irish children
| العنوان: | Adverse metabolic profiles in a cohort of obese Irish children |
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| المؤلفون: | L Teong, John J. Nolan, Mensud Hatunic, Francis M. Finucane, M. Fallon, N. Murphy, V.E.F. Crowley, C. Costigan, Siobhan T. Pittock |
| المصدر: | Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 45:206-209 |
| بيانات النشر: | SAGE Publications, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Blood Glucose, Male, medicine.medical_specialty, Waist, Adolescent, medicine.medical_treatment, Clinical Biochemistry, Carbohydrate metabolism, Body Mass Index, Cohort Studies, Insulin resistance, Internal medicine, Humans, Medicine, Obesity, Child, medicine.diagnostic_test, business.industry, Insulin, Puberty, Alanine Transaminase, General Medicine, medicine.disease, Fatty Liver, Blood pressure, Endocrinology, Body Constitution, Female, Insulin Resistance, business, Lipid profile, Ireland, Body mass index, Biomarkers |
| الوصف: | Background The metabolic characteristics of obese Irish children are not well defined. We prospectively examined the relationship between the degree of obesity and glucose metabolism, insulin sensitivity and suspected non-alcoholic steatohepatosis (NASH) in a pilot study of obese Irish children. Methods We measured height, weight, body mass index (BMI), blood pressure, waist and hip circumference in 18 participants (mean age 15.5 years). Fasting blood glucose, insulin, lipid profile and alanine aminotransferase (ALT) concentrations were also measured. A standard 75 g oral glucose tolerance test was performed and insulin sensitivity was derived from this using a mathematical model – oral glucose insulin sensitivity. Results There were significant associations between the degree of obesity, insulin sensitivity and markers of liver steatosis. For example, when adjusted for pubertal status, there were significant associations between standardized BMI and insulin sensitivity (regression coefficient, β= −70.1, P= 0.018) and ALT ( β= 20.7, P= 0.007) Conclusion This study suggests that the degree of obesity is associated with lower insulin sensitivity and possible NASH in obese Irish children. |
| تدمد: | 1758-1001 0004-5632 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea18c8799d8d9cad625302c1a7990d9Test https://doi.org/10.1258/acb.2007.007115Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....6ea18c8799d8d9cad625302c1a7990d9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17581001 00045632 |
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