Brain Pathology in Adult Rats Treated With Domoic Acid
| العنوان: | Brain Pathology in Adult Rats Treated With Domoic Acid |
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| المؤلفون: | Roberto Bermúdez, M. López Peña, José Manuel Cifuentes, Andrés C. Vieira, Nuria Alemañ, Luis M. Botana |
| المصدر: | Veterinary Pathology. 52:1077-1086 |
| بيانات النشر: | SAGE Publications, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Neurotoxins, Hippocampus, Biology, Microgliosis, Nitric oxide, chemistry.chemical_compound, medicine, Animals, Neurotoxin, Kainic Acid, General Veterinary, Pyramidal Cells, Olfactory tubercle, Neurotoxicity, Brain, Septal nuclei, medicine.disease, Immunohistochemistry, Rats, medicine.anatomical_structure, nervous system, chemistry, Female, Astrocytosis |
| الوصف: | Domoic acid (DA) is a neurotoxin reported to produce damage to the hippocampus, which plays an important role in memory. The authors inoculated rats intraperitoneally with an effective toxic dose of DA to study the distribution of the toxin in major internal organs by using immunohistochemistry, as well as to evaluate the induced pathology by means of histopathologic and immunohistochemical methods at different time points after toxin administration (6, 10, and 24 hours; 5 and 54 days). DA was detected by immunohistochemistry exclusively in pyramidal neurons of the hippocampus at 6 and 10 hours after dosing. Lesions induced by DA were prominent at 5 days following treatment in selected regions of the brain: hippocampus, amygdala, piriform and perirhinal cortices, olfactory tubercle, septal nuclei, and thalamus. The authors found 2 types of lesions: delayed death of selective neurons and large areas of necrosis, both accompanied by astrocytosis and microgliosis. At 54 days after DA exposure, the pathology was characterized by still-distinguishable dying neurons, calcified lesions in the thalamus, persistent astrocytosis, and pronounced microgliosis. The expression of nitric oxide synthases suggests a role for nitric oxide in the pathogenesis of neuronal degeneration and chronic inflammation induced by DA in the brain. |
| تدمد: | 1544-2217 0300-9858 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af7bc7564d0beaf8b408d470400c4e2bTest https://doi.org/10.1177/0300985815584074Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....af7bc7564d0beaf8b408d470400c4e2b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15442217 03009858 |
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