التفاصيل البيبلوغرافية
| العنوان: |
Programmed Death-ligand 1 Expression With Clone 22C3 in Non-small Cell Lung Cancer: A Single Institution Experience |
| المؤلفون: |
Takeda, Maiko, Kasai, Takahiko, Naito, Maiko, Tamiya, Akihiro, Taniguchi, Yoshihiko, Saijo, Nobuhiko, Naoki, Yoko, Okishio, Kyoichi, Shimizu, Shigeki, Kojima, Kensuke, Nagoya, Akihiro, Sakamoto, Tetsuki, Utsumi, Tomoki, Yoon, Hyung-Eun, Matsumura, Akihide, Atagi, Shinji |
| المصدر: |
Clinical Medicine Insights: Oncology ; volume 13, page 117955491882131 ; ISSN 1179-5549 1179-5549 |
| بيانات النشر: |
SAGE Publications |
| سنة النشر: |
2019 |
| الوصف: |
Background: In recent years, the anti-programmed cell death 1 (PD-1) drug pembrolizumab (Keytruda) was approved for treatment of unresectable advanced non-small cell lung cancer (NSCLC) as first- or second-line therapy depending on the clone 22C3-programmed death-ligand 1 (PD-L1) immunohistochemical expression score by the companion diagnostic assay. We herein evaluated 22C3-PD-L1 expression of NSCLC in a single institution experience and compared it with clinicopathologic features. Materials and methods: We assessed 22C3-PD-L1 expressions of 411 patients with NSCLC from our institution, including in past specimens. Programmed death-ligand 1 immunohistochemistry (IHC) testing was performed using the PD-L1 clone 22C3 pharmDx kit (Agilent Technologies/Dako, Carpinteria, CA, USA). Patients were separated into 3 groups with <1% (no expression), 1% to 49% (low expression), or ⩾50% (high expression) positive tumor cells. Results: In all, 137 patients (33%) did not express PD-L1, 155 (38%) showed low expression, and 119 (29%) demonstrated high expression. Archival samples showed lower PD-L1 expression than that of recent samples, and the ratios of no expression case significantly increased by using paraffin blocks embedded particularly in more than 4 years ago. Programmed death-ligand 1 positivity was significantly associated with male sex, smoking, higher tumor grade, squamous cell carcinoma in histologic type, wild-type EGFR, and ALK rearrangement positive. Conclusions: The rate of 22C3-PD-L1 expression of NSCLC detected in this study was similar to the frequencies of the previous reports, although the ratio of expression case decreased when using old paraffin blocks. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1177/1179554918821314 |
| الإتاحة: |
https://doi.org/10.1177/1179554918821314Test |
| حقوق: |
http://journals.sagepub.com/page/policies/text-and-data-mining-licenseTest |
| رقم الانضمام: |
edsbas.B8BD14E0 |
| قاعدة البيانات: |
BASE |
