التفاصيل البيبلوغرافية
| العنوان: |
Lipid peroxidation and changes in major antioxidant markers in copper quinolate fungicide-exposed rats |
| المؤلفون: |
Baali, B, Kirane-Amrani, L, Tichati, L, Soual, R, Ouali, K |
| المساهمون: |
National Fund for Scientific Research of Algeria |
| المصدر: |
Toxicology and Industrial Health ; volume 39, issue 11, page 664-678 ; ISSN 0748-2337 1477-0393 |
| بيانات النشر: |
SAGE Publications |
| سنة النشر: |
2023 |
| مصطلحات موضوعية: |
Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health, Toxicology |
| الوصف: |
The present study investigated the toxic effects of sub-chronic exposure to copper quinolate (CuQ) fungicide on liver and kidney function. Twenty-four adult male Wistar rats were equally divided into a control group, and three treated groups received, respectively, by oral gavage, three increasing doses of CuQ: 47; 67.1; and 94 mg/kg b.w corresponding, respectively, LD 50 /100, LD 50 /70, and LD 50 /50 daily for 8 weeks. CuQ resulted in a significant increase in the serum enzymatic activity of aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and the serum levels of urea, creatinine, uric acid, and malondialdehyde, along with a marked decrease in alanine aminotransferase (ALT) activity, and the contents of total protein and albumin compared to those of the control group. Furthermore, glutathione content and the enzymatic activity of superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), and glutathione peroxidase (GPx) decreased significantly in a dose-dependent manner with respect to CuQ. The adverse effects of CuO were supported by the histopathological evaluations of liver and kidney tissues. Conclusively, sub-chronic CuQ exposure was shown to induce kidney and liver oxidative damage and dysfunction. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1177/07482337231203075 |
| الإتاحة: |
https://doi.org/10.1177/07482337231203075Test |
| حقوق: |
http://journals.sagepub.com/page/policies/text-and-data-mining-licenseTest |
| رقم الانضمام: |
edsbas.3F0AAEE6 |
| قاعدة البيانات: |
BASE |
