Genetic Associations between Delusional Disorder and Paranoid Schizophrenia: A Novel Etiologic Approach
| العنوان: | Genetic Associations between Delusional Disorder and Paranoid Schizophrenia: A Novel Etiologic Approach |
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| المؤلفون: | Tapas Kumar Chaudhuri, Nirmal Kumar Bera, Monojit Debnath, Sujit K. Das, Chitta R. Nayak |
| المصدر: | The Canadian Journal of Psychiatry. 51:342-349 |
| بيانات النشر: | SAGE Publications, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Adult, Male, Paranoid schizophrenia, medicine.medical_specialty, Psychosis, Statistics as Topic, India, HLA-A3 Antigen, Linkage Disequilibrium, Gene Frequency, Delusion, Reference Values, mental disorders, Paraphrenia, Immunogenetics, medicine, Humans, Genetic Predisposition to Disease, Paranoia, Psychiatry, Alleles, Schizophrenia, Paranoid, HLA-A Antigens, Delusional disorder, Histocompatibility Antigens Class I, Middle Aged, medicine.disease, Psychiatry and Mental health, Schizophrenia, Case-Control Studies, Female, Paranoid Disorders, medicine.symptom, Psychology, Clinical psychology |
| الوصف: | Objectives: Genetic associations between delusional disorder and paranoid schizophrenia are not well understood, although involvement of biological factors has been suspected. We investigated the incidence of human leukocyte antigen (HLA) class I alleles in patients with delusional disorder and paranoid schizophrenia, first, to explore a possible immunogenetic etiology of these paranoid disorders and, second, to determine whether they share similar etiologic mechanisms. Method: We employed a nested case-control study design. Psychiatric reference data were available for 38 500 patients attending a hospital-based psychiatric outpatient department between 1998 and 2005. We enrolled 100 patients with delusional disorder and 50 patients with paranoid schizophrenia as the subject cases, using DSM-IV criteria. We considered equivalent numbers of healthy volunteers matched for age and ethnic background as control subjects. All subjects came from an India-born Bengali population. We applied the polymerase chain reaction-based molecular typing method to all patients and healthy subjects. Results: The HLA-A *03 gene is significantly associated with delusional disorder as well as with paranoid schizophrenia. This HLA gene alone or in linkage disequilibrium with other HLA genes or other closely linked non-HLA genes may influence susceptibility to delusional disorder and paranoid schizophrenia. Conclusions: The study reveals important associations between HLA genes and paranoid disorders. Delusional disorder and paranoid schizophrenia may share similar etiologic mechanisms. This preliminary observation may help our understanding of the genetic basis of these paranoid disorders. (Can J Psychiatry 2006;342-349) Information on funding and support and author affiliations appears at the end of the article. Key Words: delusion, paranoid schizophrenia, etiology, human leukocyte antigens, association, paranoid symptoms Paranoid symptoms are among the most dramatic and serious disturbances in psychiatry and medicine. Paranoid symptoms commonly seen in various psychiatric disorders are known as the "paranoid spectrum" (1). Kraepelin (1856 to 1926) clearly described paranoia and included it in a continuum of illnesses with delusional features, which also subsumed paraphrenia and paranoid schizophrenia (2). Since Kraepelin's time, many psychiatrists have believed that paranoia-delusional disorder and paranoid schizophrenia are opposite ends of a continuum of psychotic disorders that have delusions as a prominent feature (2). However, controversy continues as to whether the paranoid (delusional) psychoses belong within, or are separate from, the schizophrenia disorders. The nosologie approaches to paranoid schizophrenia and paranoid psychosis differ substantially (3). Family studies have played a central role in the controversy over the nosologie status of paranoid psychosis or delusional disorder. In 1987, the revised third edition of the DSM distinguished delusional (paranoid) disorder from paranoid schizophrenia (4). Delusional disorder, a psychosis previously called "paraphrenia" (5), is characterized by monosymptomatic paranoid symptoms. Delusions are considered as the basic factor responsible for the severity of many neuropsychiatrie as well as medical conditions. However, research has not investigated the underlying psychopathology of such delusional manifestation in variable diseases. Many studies have explored the possibility of relating delusional disorder to other disorders such as schizophrenia and affective diseases. Delusional disorders are usually thought to overlap with schizophrenic disorders, and there may be a continuum with paranoid schizophrenia (6). Although paranoid schizophrenia is invariably grouped with other schizophrenia subtypes,there is still justification for Kraepelin's original concept of its belonging with the delusional disorders (7). Huge controversy still exists, without any biological support. … |
| تدمد: | 1497-0015 0706-7437 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb040a8382864a07c459b596d8094d99Test https://doi.org/10.1177/070674370605100602Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....eb040a8382864a07c459b596d8094d99 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14970015 07067437 |
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