Double Immunolabeling by the RBM and the PLAP Markers for Identifying Intratubular (in Situ) Germ Cell Neoplasia of the Testis
| العنوان: | Double Immunolabeling by the RBM and the PLAP Markers for Identifying Intratubular (in Situ) Germ Cell Neoplasia of the Testis |
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| المؤلفون: | Jolanta Słowikowska-Hilczer, Krzysztof Kula, Beatriz Lifschitz-Mercer, Letizia Schreiber, Batia Bar-Shira Maymon, Haim Yavetz, David J. Elliott, Gedalia Paz |
| المصدر: | International Journal of Surgical Pathology. 11:17-20 |
| بيانات النشر: | SAGE Publications, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Pathology, medicine.medical_specialty, Testicular Neoplasm, Biology, GPI-Linked Proteins, Y chromosome, Pathology and Forensic Medicine, Immunoenzyme Techniques, Lesion, 03 medical and health sciences, Immunolabeling, 0302 clinical medicine, Testicular Neoplasms, Biomarkers, Tumor, medicine, Humans, Fluorescent Antibody Technique, Indirect, Carcinoma in situ, Intratubular germ cell neoplasia, RNA-Binding Proteins, Alkaline Phosphatase, medicine.disease, Molecular biology, Isoenzymes, 030104 developmental biology, Placental alkaline phosphatase, Child, Preschool, 030220 oncology & carcinogenesis, Immunohistochemistry, Surgery, Germinoma, Anatomy, medicine.symptom, Carcinoma in Situ |
| الوصف: | Identification of intratubular germ cell neoplasia (carcinoma in situ, CIS) of the testis is a diagnostic challenge, and markers are sorely needed to assist in accurately identifying the lesion. RNA-binding motif (RBM) protein, encoded by the Y chromosome, is expressed exclusively and consistently in differentiated male germ cells, while it is absent in neoplastic germ cells. Another immunohistochemical marker, placental alkaline phosphatase (PLAP), is commonly used for the detection of undifferentiated germ cells. The current study demonstrates that simultaneous use of the immunohistochemical markers, RBM and PLAP, by double immunolabeling enhances the accuracy of diagnosing CIS, a preinvasive testicular neoplasm. |
| تدمد: | 1940-2465 1066-8969 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a6dc304f986f6517ecdbcbe15365258Test https://doi.org/10.1177/106689690301100104Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....3a6dc304f986f6517ecdbcbe15365258 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19402465 10668969 |
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