Identification of key genes and novel immune infiltration-associated biomarkers of sepsis
| العنوان: | Identification of key genes and novel immune infiltration-associated biomarkers of sepsis |
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| المؤلفون: | Meng Wu, Chao Xu, Jinling Ma, Wendan Tian, Jian-bo Xu, Ling Lu |
| المصدر: | Innate Immunity Innate Immunity, Vol 26 (2020) |
| بيانات النشر: | SAGE Publications, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | lcsh:Immunologic diseases. Allergy, key biomarkers, 0301 basic medicine, Immunology, Cell, Naive B cell, Biology, MMP9, Microbiology, Sepsis, 03 medical and health sciences, 0302 clinical medicine, Immune system, Cell Movement, medicine, CEBPB, Humans, Gene Regulatory Networks, KEGG, Molecular Biology, Gene, B-Lymphocytes, immune infiltration, WGCNA, CCAAT-Enhancer-Binding Protein-beta, Immunity, CIBERSORT, Computational Biology, 030208 emergency & critical care medicine, Original Articles, T-Lymphocytes, Helper-Inducer, Cell Biology, Prognosis, medicine.disease, Receptors, Complement, Killer Cells, Natural, Gene Ontology, 030104 developmental biology, Infectious Diseases, medicine.anatomical_structure, Matrix Metalloproteinase 9, lcsh:RC581-607, Biomarkers |
| الوصف: | Sepsis is the major cause of mortality in the intensive care unit. The aim of this study was to identify the key prognostic biomarkers of abnormal expression and immune infiltration in sepsis. In this study, a total of 36 differentially expressed genes were identified to be mainly involved in a number of immune-related Gene Ontology terms and Kyoto Encyclopedia of Genes and Genomes pathways. The hub genes ( MMP9 and C3AR1) were significantly related to the prognosis of sepsis patients. The immune infiltration analysis indicated a significant difference in the relative cell content of naive B cells, follicular Th cells, activated NK cells, eosinophils, neutrophils and monocytes between sepsis and normal controls. Weighted gene co-expression network analysis and a de-convolution algorithm that quantifies the cellular composition of immune cells were used to analyse the sepsis expression data from the Gene Expression Omnibus database and to identify modules related to differential immune cells. CEBPB is the key immune-related gene that may be involved in sepsis. Gene set enrichment analysis revealed that CEBPB is involved in the processes of T cell selection, B cell–mediated immunity, NK cell activation and pathways of T cells, B cells and NK cells. Therefore, CEBPB may play a key role in the biological and immunological processes of sepsis. |
| تدمد: | 1753-4267 1753-4259 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4022a5940b71c567f183b63507d3bfacTest https://doi.org/10.1177/1753425920966380Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4022a5940b71c567f183b63507d3bfac |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17534267 17534259 |
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