التفاصيل البيبلوغرافية
| العنوان: |
Mood stabilizer treatment increases serotonin type 1A receptor binding in bipolar depression |
| المؤلفون: |
Nugent, Allison C, Carlson, Paul J, Bain, Earle E, Eckelman, William, Herscovitch, Peter, Manji, Husseini, Zarate, Carlos A, Drevets, Wayne C |
| المصدر: |
Journal of Psychopharmacology ; volume 27, issue 10, page 894-902 ; ISSN 0269-8811 1461-7285 |
| بيانات النشر: |
SAGE Publications |
| سنة النشر: |
2013 |
| مصطلحات موضوعية: |
Pharmacology (medical), Psychiatry and Mental health, Pharmacology |
| الوصف: |
Abnormal serotonin type 1A (5-HT 1A ) receptor function and binding have been implicated in the pathophysiology of mood disorders. Preclinical studies have consistently shown that stress decreases the gene expression of 5-HT 1A receptors in experimental animals, and that the associated increase in hormone secretion plays a crucial role in mediating this effect. Chronic administration of the mood stabilizers lithium and divalproex (valproate semisodium) reduces glucocorticoid signaling and function in the hippocampus. Lithium has further been shown to enhance 5-HT 1A receptor function. To assess whether these effects translate to human subject with bipolar disorder (BD), positron emission tomography (PET) and [18F]trans-4-fluoro-N-(2-[4-(2-methoxyphenyl) piperazino]-ethyl)-N-(2-pyridyl) cyclohexanecarboxamide ([ 18 F]FCWAY) were used to acquire PET images of 5-HT 1A receptor binding in 10 subjects with BD, before and after treatment with lithium or divalproex. Mean 5-HT 1A binding potential (BP P ) significantly increased following mood stabilizer treatment, most prominently in the mesiotemporal cortex (hippocampus plus amygdala). When mood state was also controlled for, treatment was associated with increases in BP P in widespread cortical areas. These preliminary findings are consistent with the hypothesis that these mood stabilizers enhance 5-HT 1A receptor expression in BD, which may underscore an important component of these agents’ mechanism of action. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1177/0269881113499204 |
| الإتاحة: |
https://doi.org/10.1177/0269881113499204Test |
| حقوق: |
http://journals.sagepub.com/page/policies/text-and-data-mining-licenseTest |
| رقم الانضمام: |
edsbas.4D15FDC2 |
| قاعدة البيانات: |
BASE |
