Low Density Lipoprotein Apolipoprotein B Metabolism in Treatment-Naive HIV Patients and Patients on Antiretroviral Therapy
| العنوان: | Low Density Lipoprotein Apolipoprotein B Metabolism in Treatment-Naive HIV Patients and Patients on Antiretroviral Therapy |
|---|---|
| المؤلفون: | Maryam Shahmanesh, Nicola Jackson, Fariba Shojaee-Moradie, S. Das, M Stolinski, Peter Nightingale, Anne Umpleby, W Jefferson, NJ Crabtree |
| المصدر: | Scopus-Elsevier |
| بيانات النشر: | SAGE Publications, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Pharmacology, medicine.medical_specialty, Apolipoprotein B, biology, Reverse-transcriptase inhibitor, Cholesterol, medicine.disease, chemistry.chemical_compound, Infectious Diseases, Endocrinology, chemistry, Pharmacokinetics, Low-density lipoprotein, Internal medicine, Immunology, biology.protein, medicine, Lean body mass, lipids (amino acids, peptides, and proteins), Pharmacology (medical), Ritonavir, Lipodystrophy, medicine.drug |
| الوصف: | Background Dyslipidaemia and lipodystrophy have been described in treated HIV patients and in a small percentage of untreated HIV patients. Lipodystrophy in these patients has been shown to be associated with a lower expression of low density lipoprotein (LDL) receptors. Methods We have investigated the effect of antiretroviral treatment with either a protease inhibitor (PI) or a non-nucleoside reverse transcriptase inhibitor (NNRTI) on body fat distribution and LDL apolipoprotein B (apoB) kinetics in 12 HIV-negative controls and 52 HIV-infected patients, including antiretroviral treatment-naive (TN) patients ( n=13) and patients taking two nucleoside analogues plus either a PI ( n=15) or an NNRTI ( n=24). Results LDL cholesterol was not different between groups. Compared with the controls, LDL apoB absolute synthetic rate (ASR) and fractional catabolic rate (FCR) were lower and residence time (RT) was higher in the PI and NNRTI groups ( PConclusions Decreased LDL FCR, despite unchanged LDL cholesterol, was demonstrated in both treated and untreated HIV patients. It was more marked with RTV-containing regimens and was associated with reduced limb fat. The increased LDL RT may lead to an increased risk of atherogenesis thus contributing to the risk for cardiovascular disease in these patients. |
| تدمد: | 2040-2058 1359-6535 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdbf1b1b7fd73761fb489a0ec36d7e64Test https://doi.org/10.1177/135965350501000508Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....fdbf1b1b7fd73761fb489a0ec36d7e64 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20402058 13596535 |
|---|