التفاصيل البيبلوغرافية
| العنوان: |
Cerebral blood volume lesion extent predicts functional outcome in patients with vertebral and basilar artery occlusion |
| المؤلفون: |
Alemseged, Fana, Shah, Darshan G., Dowling, Richard J., Bush, Steven, Sallustio, Fabrizio, Caltagirone, Carlo, Mercuri, Nicola B., Floris, Roberto, Parsons, Mark W., Levi, Christopher R., Mitchell, Peter J., Davis, Stephen M., Bivard, Andrew, Campbell, Bruce C. V., Kleinig, Timothy J., Yassi, Nawaf, Diomedi, Marina, Di Giuliano, Francesca, Sharma, Gagan, Drew, Roy, Yan, Bernard |
| المساهمون: |
The University of Newcastle. Faculty of Health & Medicine, School of Medicine and Public Health |
| بيانات النشر: |
Sage Publications |
| سنة النشر: |
2019 |
| المجموعة: |
NOVA: The University of Newcastle Research Online (Australia) |
| مصطلحات موضوعية: |
cerebral blood volume, lesion, Sustainable Development Goals, SDG 3, perfusion imaging, vertebrobasilar disease, prognosis, aspects, reperfusion, stroke, vertebral artery occlusion, basilar artery occlusion |
| الوصف: |
Background: CT perfusion may improve diagnostic accuracy in posterior circulation stroke. The posterior circulation Acute Stroke Prognosis Early CT score (pc-ASPECTS) on Computed Tomography Angiography source images (CTA-SI)predicts functional outcome in patients with basilar artery occlusion. Aims: We assessed the prognostic value of pc-ASPECTS on CT perfusion in patients with vertebral and basilar arteryocclusion (VBAO) in comparison with CTA-SI. Methods: Whole-brain CT perfusion from consecutive stroke patients with VBAO at four stroke centers was retrospectively analyzed. pc-ASPECTS – a 10-point score assessing hypoattenuation on CTA-SI – was calculated from CTperfusion parameters as focally reduced cerebral blood flow or cerebral blood volume, focally increased time to peak ofthe deconvolved tissue residue function (Tmax) or mean transit time. Two investigators independently reviewed theimages. Reliability was assessed with intraclass correlation coefficient. Good outcome was defined as modified Rankin scale <3 at three months.Results: We included 60 patients with VBAO. After assessment of four CT perfusion maps simultaneously, area-under-ROC curve (AROC) was 0.83 (95%CI 0.72–0.93) for cerebral blood volume, 0.76 (95%CI 0.64–0.89) for cerebral blood flow, 0.77 (95%CI 0.64–0.89) for Tmax, 0.70 (95%CI 0.56–0.84) for mean transit time versus area-under-ROC curve 0.64 (95%CI 0.50–0.79) for CTA-SI. Cerebral blood volume had greater accuracy compared with CTA-SI for poor outcome (p 1/4 0.04). In logistic regression analysis, cerebral blood volume pc-ASPECTS <8 was independently associated with poor outcome (OR 9.3 95%CI 2.2–41; p 1/4 0.003, adjusted for age and clinical severity). Inter-rater agreement was substantial for cerebral blood volume pc-ASPECTS (intraclass correlation coefficient 0.82 95%CI 0.71–0.90 versus 0.67 for CTA-SI 95% CI 0.43–0.81). Conclusions: Cerebral blood volume pc-ASPECTS may identify VBAO patients at higher risk of disability. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| تدمد: |
1747-4930 |
| العلاقة: |
NHMRC.GNT1043242 & NHMRC.GNT1111972http://purl.org/au-research/grants/nhmrc/GNT1111972; International Journal of Stroke Vol. 14, Issue 5, p. 540-547; http://hdl.handle.net/1959.13/1433213Test; uon:39183 |
| الإتاحة: |
http://hdl.handle.net/1959.13/1433213Test |
| رقم الانضمام: |
edsbas.D8125A7D |
| قاعدة البيانات: |
BASE |
