Safety and Efficacy of Sunitinib in Patients with Unresectable Pancreatic Neuroendocrine Tumors
| العنوان: | Safety and Efficacy of Sunitinib in Patients with Unresectable Pancreatic Neuroendocrine Tumors |
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| المؤلفون: | Marcus W. Wiedmann, Joachim Mössner |
| المصدر: | Clinical Medicine Insights: Oncology, Vol 6 (2012) Clinical Medicine Insights. Oncology Clinical Medicine Insights: Oncology, Vol 2012, Iss 6, Pp 381-393 (2012) |
| بيانات النشر: | SAGE Publications, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | pancreatic neuroendocrine tumors, Sunitinib, business.industry, sunitinib, medicine.medical_treatment, Cancer, Stem cell factor, Review, Neuroendocrine tumors, everolimus, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, lcsh:RC254-282, Targeted therapy, Colony stimulating factor 1 receptor, Oncology, Growth factor receptor, Neurotrophic factors, Cancer research, medicine, business, medicine.drug, Biomedical engineering |
| الوصف: | Pancreatic neuroendocrine tumors (PNETs) are becoming increasingly common, with the majority of patients presenting with either lymph node involvement or metastatic disease, thus requiring systemic therapy. Targeted therapy is a type of medication that blocks the growth of cancer cells by interfering with specific targeted molecules needed for carcinogenesis and tumor growth rather than by simply interfering with rapidly dividing cells (eg, with traditional chemotherapy). In this review article, pharmacologic inhibition of multiple targets including vascular endothelial growth factor receptor (VEGF-R), platelet-derived growth factor receptor (PDGF-R), stem cell factor receptor (c-KIT-R), FML-like tyrosine kinase-3 receptor (FLT3-R), colony stimulating factor 1 receptor (CSF1-R), and glial cell-line derived neurotrophic factor receptor (RET-R) with sunitinib in patients with unresectable PNETs is discussed. Phase III data indicate that additional treatment with sunitinib can improve prognosis in these patients. |
| تدمد: | 1179-5549 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd6db61d4a0039656dd91c6a9b3dd94Test https://doi.org/10.4137/cmo.s7350Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4dd6db61d4a0039656dd91c6a9b3dd94 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 11795549 |
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