Abatacept in psoriatic arthritis: Case report and short review
| العنوان: | Abatacept in psoriatic arthritis: Case report and short review |
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| المؤلفون: | Rosa Daniela Grembiale, Emilio Russo, Francesco Ursini, Saverio Naty |
| المساهمون: | Ursini F., Naty S., Russo E., Grembiale R. |
| المصدر: | Journal of Pharmacology & Pharmacotherapeutics |
| بيانات النشر: | SAGE Publications, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | psoriatic arthritis, musculoskeletal diseases, Pharmacology, medicine.medical_specialty, business.industry, Abatacept, psoriasis, Case Review, medicine.disease, Chronic inflammatory disease, Dermatology, NO, Pathogenesis, Psoriatic arthritis, Antigen, Psoriasis, Rheumatoid arthritis, medicine, Physical therapy, Cytotoxic T cell, Pharmacology (medical), business, psoriasi, medicine.drug |
| الوصف: | Psoriatic arthritis (PsA) is a chronic inflammatory disease affecting about 6-10% of patients with cutaneous psoriasis. According to current knowledge, activated T-cells seem to play a pivotal role in the pathogenesis of both psoriasis and PsA. Abatacept is a novel biologic agent selectively designed to interfere with T-cells co-stimulation. Structurally, it is a soluble, fully human fusion protein consisting of the extracellular domain of CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) linked to a modified Fc portion of human IgG1. Abatacept is now approved as a first-line treatment for rheumatoid arthritis (RA), but preliminary data disclose a potential role of abatacept in the treatment of other autoimmune diseases. In this article, we report a case of successful treatment with abatacept of a psoriatic arthritis patients who developed adverse drug reactions (ADRs) to medication commonly used in PsA, including three different anti-TNF-α agents. In addition, we review the scientific evidences supporting a possible role of abatacept in treatment of patients with psoriasis and PsA and the paradox of abatacept-induced psoriasis. |
| وصف الملف: | STAMPA |
| تدمد: | 0976-5018 0976-500X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edfa1eb3b40afd672d16527e16a6a7e6Test https://doi.org/10.4103/0976-500x.120943Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....edfa1eb3b40afd672d16527e16a6a7e6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09765018 0976500X |
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