Role of Sorafenib in Patients With Recurrent Hepatocellular Carcinoma After Liver Transplantation
| العنوان: | Role of Sorafenib in Patients With Recurrent Hepatocellular Carcinoma After Liver Transplantation |
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| المؤلفون: | Daniel Azoulay, Philippe Compagnon, Filippo Landi, Julien Calderaro, Cyrille Feray, Anais Palen, Marco Nencioni, Eylon Lahat, Alain Luciani, Nicola de’Angelis, Chetana Lim, Charlotte Costentin, Chady Salloum |
| المصدر: | Progress in Transplantation. 26:348-355 |
| بيانات النشر: | SAGE Publications, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Niacinamide, Sorafenib, Oncology, medicine.medical_specialty, Carcinoma, Hepatocellular, medicine.medical_treatment, Antineoplastic Agents, Context (language use), Liver transplantation, Milan criteria, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, In patient, Retrospective Studies, Transplantation, business.industry, Phenylurea Compounds, Liver Neoplasms, medicine.disease, digestive system diseases, Recurrent Hepatocellular Carcinoma, Liver Transplantation, Treatment Outcome, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, 030211 gastroenterology & hepatology, Neoplasm Recurrence, Local, business, medicine.drug |
| الوصف: | Context: The management of hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) is challenging, especially if it is not treatable by surgery or embolization. Objectives: The present study aims to compare the survival rates of liver transplanted patients receiving sorafenib or best supportive care (BSC) for HCC recurrence not amenable to curative intent treatments. Design: This is a retrospective comparative study on a prospectively maintained database. Participants: Liver transplanted patients with untreatable HCC recurrence receiving BSC (n = 18) until 2007 or sorafenib (n = 15) thereafter were compared. Results: No group difference was observed for demographic characteristics at the time of transplantation and at the time of HCC recurrence. On the explant pathology of the native liver, 81.2% patients were classified within the Milan criteria, and 53.1% presented with microvascular invasion. Hepatocellular carcinoma recurrence was diagnosed 17.8 months (standard deviation: 14.5) after LT, with 17 (53.1%) patients presenting with early recurrence (≤12 months). The 1-year survival from untreatable progression of HCC recurrence was 23.9% for the BSC and 60% for the sorafenib group ( P = .002). The type of treatment (sorafenib vs BSC) was the sole independent predictor of survival (hazard ratio: 2.98; 95% confidence interval: 1.09-8.1; P = .033). In the sorafenib group, 8 (53.3%) patients required dose reduction, and 2 (13.3%) patients discontinued the treatment due to intolerable side effects. Conclusion: Sorafenib improves survival and is superior to the BSC in cases of untreatable posttransplant hepatocellular carcinoma recurrence. |
| تدمد: | 2164-6708 1526-9248 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbdda6ecc8c70ed50bc6c5cc1024b5a5Test https://doi.org/10.1177/1526924816664083Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....fbdda6ecc8c70ed50bc6c5cc1024b5a5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21646708 15269248 |
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