Phthalate Exposures and MicroRNA Expression in Uterine Fibroids: The FORGE Study
| العنوان: | Phthalate Exposures and MicroRNA Expression in Uterine Fibroids: The FORGE Study |
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| المؤلفون: | Lisa Y Hu, Ruth J. Geller, Cherie Q. Marfori, Ami R. Zota, Sana Tabbara, Andrea A. Baccarelli, Gaby N. Moawad, Brianna N VanNoy |
| المصدر: | Epigenetics Insights, Vol 13 (2020) Epigenetics Insights |
| بيانات النشر: | SAGE Publications, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | lcsh:QH426-470, Uterine fibroids, Bioinformatics, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, women’s health, microRNA, Genetics, Medicine, Epigenetics, Original Research, health disparities, 030304 developmental biology, Environmental and Nutritional Epigenetics, 2. Zero hunger, Endocrine-disrupting chemicals, 0303 health sciences, 030219 obstetrics & reproductive medicine, Uterine leiomyoma, epigenetics, business.industry, gynecology, Phthalate, medicine.disease, female genital diseases and pregnancy complications, lcsh:Genetics, Increased risk, chemistry, non-coding RNAs, business |
| الوصف: | Phthalates are associated with multiple, adverse reproductive outcomes including increased risk of uterine leiomyoma (fibroids). Phthalates can interact with epigenetic modifications including microRNAs (miRNAs), which help regulate processes crucial to fibroid pathogenesis. However, no prior study has examined the influence of phthalates on miRNA expression in fibroid tumors. We conducted a preliminary, cross-sectional study to examine the associations between phthalate exposures and miRNA expression levels in fibroid tumors and to explore potential effect modification by race/ethnicity. We quantified expression levels of 754 miRNAs in fibroid tumor samples and analyzed spot urine samples for phthalate metabolites collected from 45 pre-menopausal women undergoing surgery for fibroid treatment at an academic hospital. Associations between miRNA levels in fibroids and phthalate biomarkers were evaluated using linear regression adjusting for age, race/ethnicity, and body mass index (BMI). Statistical tests were adjusted for multiple comparisons. We also performed in silico Ingenuity Pathway Analysis to identify the biological pathways that are regulated by phthalate-associated miRNAs. Mono-hydroxybutyl phthalate and mono(2-ethyl-5-hydroxyhexyl) phthalate were positively associated with miR-10a-5p (β = 0.76, 95% CI = [0.40, 1.11]) and miR-577 (β = 1.06, 95% CI = [0.53, 1.59]), respectively. A total of 8 phthalate-miRNA associations varied by race/ethnicity (qinteraction |
| تدمد: | 2516-8657 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127155dd7fb008c7ebd80276d97b38f6Test https://doi.org/10.1177/2516865720904057Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....127155dd7fb008c7ebd80276d97b38f6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25168657 |
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