Polyuria associated with high-dose methotrexate in two patients with acute lymphoblastic leukaemia
| العنوان: | Polyuria associated with high-dose methotrexate in two patients with acute lymphoblastic leukaemia |
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| المؤلفون: | Deborah P. Jones, Aaron R. Weiss, Keith K. Lau |
| المصدر: | Journal of Oncology Pharmacy Practice. 11:31-33 |
| بيانات النشر: | SAGE Publications, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Male, Antimetabolites, Antineoplastic, medicine.medical_specialty, Adenosine, Adolescent, endocrine system diseases, Diabetes Insipidus, Nephrogenic, urologic and male genital diseases, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Polyuria, Internal medicine, medicine, Humans, Pharmacology (medical), Child, Reabsorption, business.industry, Precursor Cell Lymphoblastic Leukemia-Lymphoma, medicine.disease, Nephrogenic diabetes insipidus, female genital diseases and pregnancy complications, Leukemia, Methotrexate, Endocrinology, Oncology, 030220 oncology & carcinogenesis, Injections, Intravenous, Diabetes insipidus, Toxicity, Fluid Therapy, Female, medicine.symptom, Complication, business, 030215 immunology, medicine.drug |
| الوصف: | Although methotrexate has an established safety profile in clinical practice, severe morbidity can still occur on rare occassions. We report two patients with leukemia treated with high dose methotrexate. Both patients developed profound polyuria that required aggressive fluid resuscitations during the treatments. Renal toxicity is a known complication of methotrexate, but polyuria associated with its use has not been reported before. Polyuria started shortly after the initiation of the medicine in both patients. The polyuria resolved as the drug level in blood became undetectable. The episodes of polyuria were transient and recurred every time when the patients received methotrexate. The clinical pictures were not compatible with classical drug induced nephrogenic diabetes insipidus. It is possible that the drug interferes with adenosine metabolism, which in turn alters the tubular ability of solute and fluid reabsorption. |
| تدمد: | 1477-092X 1078-1552 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01eded4b98457455880b3ce8749c98d3Test https://doi.org/10.1191/1078155205jp148oaTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....01eded4b98457455880b3ce8749c98d3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1477092X 10781552 |
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