Zinc treatment modulates hematological and morphological changes in rat erythrocytes following arsenic exposure
| العنوان: | Zinc treatment modulates hematological and morphological changes in rat erythrocytes following arsenic exposure |
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| المؤلفون: | Devinder K. Dhawan, Payal Bhardwaj |
| المصدر: | Toxicology and Industrial Health. 35:593-603 |
| بيانات النشر: | SAGE Publications, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Erythrocytes, Antioxidant, Sodium arsenite, Health, Toxicology and Mutagenesis, medicine.medical_treatment, chemistry.chemical_element, Zinc, 010501 environmental sciences, Toxicology, 01 natural sciences, Arsenic, Hemoglobins, Leukocyte Count, 03 medical and health sciences, chemistry.chemical_compound, Internal medicine, medicine, Animals, Rats, Wistar, ARSENIC EXPOSURE, Glutathione Transferase, 030304 developmental biology, 0105 earth and related environmental sciences, chemistry.chemical_classification, 0303 health sciences, Arsenic toxicity, Public Health, Environmental and Occupational Health, Catalase, Glutathione, Rats, Enzyme, Endocrinology, chemistry, Toxicity, Microscopy, Electron, Scanning, Lipid Peroxidation |
| الوصف: | The aim of this study was to understand the effects of zinc supplementation on antioxidant defense systems, hematological indices, and erythrocyte morphology in conditions of chronic arsenic toxicity. Male Wistar rats were segregated into four groups: control, arsenic treated, zinc supplemented, and arsenic + zinc treated. The animals in the arsenic-treated group were given arsenic orally in drinking water in the form of sodium arsenite at a dose level of 100 mg L−1, and zinc was administered to zinc-treated animals in the form of zinc sulfate orally in drinking water at a dose level of 227 mg L−1. The animals were subjected to different treatments for a period of 12 weeks, and various investigations were undertaken that included serum zinc content, activity of antioxidant enzymes, and hematological indices. Further, scanning electron microscopic (SEM) studies were performed to assess morphological changes in erythrocytes. Arsenic treatment significantly reduced serum zinc concentrations, which, however, were restored to near-normal levels upon zinc supplementation. The activities of enzymes involved in antioxidant defense systems were altered in the erythrocyte lysates of arsenic-treated rats, which interestingly revealed a significant improvement upon simultaneous zinc supplementation. A significant reduction in the counts of total leukocytes, neutrophils, and lymphocytes was observed following arsenic intoxication, which came back to near control levels following zinc supplementation. Also, protective effects of zinc were evident from SEM that revealed maintenance of topographical appearances of erythrocytes in conditions of arsenic toxicity. Thus, this study clearly shows the protection afforded by zinc on erythrocytes during arsenic-induced toxicity. |
| تدمد: | 1477-0393 0748-2337 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbfb1cc9a05aa7efa84f2ccda77d943fTest https://doi.org/10.1177/0748233719878563Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....dbfb1cc9a05aa7efa84f2ccda77d943f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14770393 07482337 |
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