Reducing Heart dose during Left Breast Cancer Radiotherapy: Comparison among 3 Radiation Techniques
| العنوان: | Reducing Heart dose during Left Breast Cancer Radiotherapy: Comparison among 3 Radiation Techniques |
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| المؤلفون: | R. Canna, Vincenzo Valentini, Luigia Nardone, A. Martino, F. Catucci, Barbara Diletto, Giuseppe D'Agostino, Giovanna Mantini, Luigi Azario, Gian Carlo Mattiucci |
| المصدر: | Tumori Journal. 102:184-189 |
| بيانات النشر: | SAGE Publications, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Breast Neoplasms, 030218 nuclear medicine & medical imaging, Breath Holding, 03 medical and health sciences, breast cancer, 0302 clinical medicine, Breast cancer, medicine, Humans, radiotherapy, Aged, Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA, Early breast cancer, Deep inspiration breath-hold, business.industry, Respiration, Cancer, Heart, Radiotherapy Dosage, General Medicine, Middle Aged, medicine.disease, Radiation therapy, Left breast, Inhalation, Oncology, 030220 oncology & carcinogenesis, Cancer Radiotherapy, Female, Radiotherapy, Adjuvant, Radiotherapy, Intensity-Modulated, Radiology, Radiotherapy, Conformal, business, Nuclear medicine |
| الوصف: | Purpose Breast cancer survivors have a high risk of cardiac death as a consequence of heart irradiation during left breast tangential radiotherapy (RT). This study compares the cardiac dose delivered by standard 3D conformal tangential RT (CRT) to that delivered by prospective-gating RT (PGRT) or 5-field intensity-modulated RT (IMRT). Methods Patients with early left breast cancer, referred for adjuvant RT to our institution, were enrolled in this study. For each patient, 2 simulation computed tomography scans were acquired: the first during free breathing, and the second on prospective gating during deep inspiration breath-hold. The scans were monitored by the Varian RPM™ respiratory gating system. For each patient, 3 treatment plans were performed: a 3D-CRT and an IMRT plan, each based on the free-breathing scan, and a PGRT plan, based on the deep inspiration breath-hold scan. Dose-volume histograms were compared by means of the Friedman test. Results The median mean heart dose was 3 Gy (range 0.9-7.3 Gy) in the CRT plans, 1.9 Gy (range 0.5-3.6 Gy) in the PGRT plans, and 4.5 Gy (range 1.1-10.5 Gy) in the IMRT plans (p = 0.001). The mean heart V25 was 1.2% (range 0%-9.7%), 0% (range 0%-2.0%), and 0.2% (range 0%-7.3%) for CRT, PGRT, and IMRT plans, respectively (pConclusions Prospective-gating RT to the left breast offered the best protection of heart and lung, as well as a lower irradiation of the contralateral breast, compared to CRT or IMRT. |
| تدمد: | 2038-2529 0300-8916 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47bd6b5a255081717064a28a60577ba9Test https://doi.org/10.5301/tj.5000414Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....47bd6b5a255081717064a28a60577ba9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20382529 03008916 |
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