دورية أكاديمية
Alterations in Regional Homogeneity in Patients With Unilateral Chronic Tinnitus
| العنوان: | Alterations in Regional Homogeneity in Patients With Unilateral Chronic Tinnitus |
|---|---|
| المؤلفون: | Gentil, Anthony, Deverdun, Jeremy, Champfleur, Nicolas, Puel, Jean-Luc, Le Bars, Emmanuelle, Venail, Frédéric |
| المساهمون: | Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Institut d’Imagerie Fonctionnelle Humaine CHU Montpellier (I2FH), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Laboratoire Charles Coulomb (L2C), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Service d'ORL, Hôpital Gui de Chauliac (CHRU de Montpellier) |
| المصدر: | EISSN: 2331-2165 ; Trends in Hearing ; https://hal.umontpellier.fr/hal-02863307Test ; Trends in Hearing, SAGE Publications, 2019, 23, pp.233121651983023. ⟨10.1177/2331216519830237⟩ |
| بيانات النشر: | HAL CCSD SAGE Publications SAGE Publishing |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | tinnitus, resting state, magnetic resonance imaging, functional neuroimaging, brain regional connectivity, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], psy, socio |
| الوصف: | International audience ; Chronic subjective tinnitus is a widespread disorder. This perceptual anomaly is assumed to result from a dysbalance of excitatory and inhibitory mechanisms on different levels of the auditory pathways. However, the brain areas involved are still under discussion. Using resting-state functional magnetic resonance imaging, we investigate differences in cerebral regional homogeneity (ReHo) between patients with unilateral chronic tinnitus and nontinnitus control subjects. To our knowledge, our study is the first to investigate the intraregional connectivity of patients with unilateral tinnitus in relation to hearing loss. Our analyses, based on strict recruitment and characterization of the participants, showed reduced ReHo in the primary auditory cortex contralateral to the side of the perceived tinnitus percept in patients. Reduced ReHo in this same region was also correlated with increased Tinnitus Handicap Inventory and Visual Analogue Scale for loudness scores, reflecting an alteration of synchronization in this region related to the perceived loudness of the tinnitus and the related distress. Furthermore, increased ReHo in the supramarginal and angular gyri ipsilateral to the tinnitus side was correlated with increased tinnitus duration and hearing threshold at the tinnitus pitch. The correlations observed in these brain areas, which are normally related to the nontinnitus ear, could highlight compensatory mechanisms in these secondary auditory regions. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://hal.umontpellier.fr/hal-02863307/file/2331216519830237%20%281%29.pdfTest; https://hal.umontpellier.fr/hal-02863307Test |
| الإتاحة: | https://doi.org/10.1177/2331216519830237Test https://hal.umontpellier.fr/hal-02863307/file/2331216519830237%20%281%29.pdfTest https://hal.umontpellier.fr/hal-02863307Test |
| حقوق: | undefined |
| رقم الانضمام: | edsbas.EFB1304A |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |