دورية أكاديمية
Response to Plasma Exchange and Steroids as Combined Therapy for Patients with Thrombotic Thrombocytopenic Purpura
| العنوان: | Response to Plasma Exchange and Steroids as Combined Therapy for Patients with Thrombotic Thrombocytopenic Purpura |
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| المؤلفون: | de la Rubia, Javier, López, Aurelio, Arriaga, Francisco, Cid, Ana Rosa, Vicente, Ana Isabel, Marty, Maria Luisa, Sanz, Miguel A. |
| المصدر: | Acta Haematologica ; volume 102, issue 1, page 12-16 ; ISSN 0001-5792 1421-9662 |
| بيانات النشر: | S. Karger AG |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Hematology, General Medicine |
| الوصف: | We describe our experience in the management of 11 consecutive patients with thrombotic thrombocytopenic purpura (TTP) treated with a combined therapy of plasma exchange (PE) and steroids. Nine patients (82%) achieved complete remission (CR) after a median of 6 rounds of PE (range 2–22). There were 3 early relapses managed in the same way as the initial episode. One patient relapsed 23 months after diagnosis achieving CR with standard therapy; another patient suffered several relapses, and splenectomy was performed after the last one. Three patients died, 2 of them with resistant disease 9 and 38 days after diagnosis, and the remaining one died due to AIDS-related complications while he was in CR. Eight patients are alive in CR with a median follow-up of 38 months (range 8–74). The combination of PE and steroids is a well-tolerated and effective treatment of TTP, but improvements in therapy are needed to manage refractory patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1159/000040961 |
| الإتاحة: | https://doi.org/10.1159/000040961Test https://www.karger.com/Article/Pdf/40961Test |
| حقوق: | https://www.karger.com/Services/SiteLicensesTest ; https://www.karger.com/Services/SiteLicensesTest |
| رقم الانضمام: | edsbas.BA037332 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1159/000040961 |
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